ALS Protein Biology Postdoc: Pathway Discovery & Imaging

University Medical Center Utrecht (UMC Utrecht); Utrecht; On-site; EUR 38,000 - 45,000; Full time

Job summary

University Medical Center Utrecht (UMC Utrecht) is seeking a postdoctoral researcher to investigate ALS mechanisms at the protein level in human tissue and neuronal models. You will study localization of disease-associated proteins, characterize cell states, and explore how newly implicated ALS genes influence pathology.

The role includes developing multiplexed imaging panels, collaborating with a team of scientists, and mentoring PhD/MSc students.

Qualifications

• PhD in neuroscience, molecular/cell biology, neuropathology, or biomedical sciences.
• Strong hands-on experience in experimental molecular/cellular biology, especially immunostaining and protein analysis.
• Experience in immunohistochemistry/immunocytochemistry with antibody optimization/validation.
• Excellent communication and mentorship skills for supervising PhD/MSc students.

Responsibilities

• Investigate protein-level localization and pathway alterations in ALS tissue.
• Develop antibody panels and optimize staining protocols for high-dimensional imaging.
• Collaborate with technicians and mentors to guide PhD/MSc students.

Skills

Experimental design

Immunostaining

Fluorescence microscopy

Protein analysis

Communication skills

Mentorship of PhD/MSc students

Education

PhD in neuroscience or related field

Tools

Immunohistochemistry

Immunocytochemistry

CRISPR gene editing

iPSC-derived neurons

Spatial proteomics

Job description

University Medical Center Utrecht (UMC Utrecht) is seeking a postdoctoral researcher to investigate ALS mechanisms at the protein level in human tissue and neuronal models. You will study localization of disease-associated proteins, characterize cell states, and explore how newly implicated ALS genes influence pathology.

The role includes developing multiplexed imaging panels, collaborating with a team of scientists, and mentoring PhD/MSc students.