Postdoctoral researcher in Neurobiology Multiple Sclerosis

University Medical Centre Groningen (UMCG); Netherlands; On-site; EUR 60,000 - 71,000; Full time

Benefits offered by this job

8% holiday allowance

8.3% year-end bonus

Job summary

University Medical Centre Groningen (UMCG) is offering a full-time junior postdoctoral position in neuroscience, funded through Stichting MS Research. The project focuses on deciphering multiple sclerosis lesion evolution using multi-omics platforms, including proteomics, phosphoproteomics, and long-read RNA sequencing.

Remote work is not indicated; a collaborative, English-speaking lab environment is expected.

Qualifications

• Junior Postdoc with a PhD in molecular cell biology or related field.
• Strong English written and spoken communication skills.
• Affinity for neuroscience and a strong scientific drive.
• Willingness to work in a collaborative, team-based environment.

Responsibilities

• Build on MS lesion evolution research by decoding region-distinct cellular signaling.
• Generate and integrate global proteomic and phosphoproteomic signatures of MS lesion rims and cores.
• Combine region-specific long-read RNA sequencing with proteomic data to link signaling changes to molecular processes.

Skills

English communication

Team player

Flexible attitude

Proactive mindset

Education

PhD in molecular cell biology or related field

Tools

Bioinformatic analysis

Job description

University Medical Centre Groningen (UMCG)

Organisation/Company University Medical Centre Groningen (UMCG) Research Field Neurosciences » Neurobiology Researcher Profile Recognised Researcher (R2) Application Deadline 18 Nov 2026 - 23:00 (UTC) Country Netherlands Type of Contract Temporary Job Status Not Applicable Hours Per Week 36.0 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system characterized by neuroinflammation and neurodegeneration. Current disease-modifying therapies are non-curative and do not reverse progression. On the level of tissue, MS lesion progression is prevented by remyelination, a natural regeneration process after demyelination that is crucial for functional recovery and neuronal survival. In this project, you will build further on our research aimed at deciphering MS lesion evolution by decoding region-distinct differences in cellular signaling and regulatory networks. You will generate and integrate global proteomic and phosphoproteomic signatures of MS lesion rims and cores in parallel with region-specific long-read RNA sequencing. This will allow you to link changes in signaling networks and RNA- and protein isoforms to molecular processes involved in lesion expansion and lesion transition. This multi-omics data approach will further the functional disentangling of molecular and cellular pathways underlying ongoing demyelination in lesion rims and successful remyelination or remyelination failure in lesion cores. The novel layer of changes in RNA and protein diversity will advance our understanding of MS and may thereby identify novel therapeutic targets.

The position is funded by Stichting MS Research.

A junior Postdoc with a PhD degree in molecular cell biology or a related field. We are looking for an enthusiastic, highly motivated and talented postdoctoral researcher with affinity for neuroscience and a strong scientific drive. Expertise with bioinformatic analysis is an advantage. Furthermore, you will need a flexible working attitude, team player mentality, good oral and written communication skills in English, and a result-driven and pro-active attitude.

Additional Information

This is a full-time junior postdoc position for a temporary contract of 12 months, preferably starting in January 2027, with the possibility of an extension for at least 12 months. The starting salary is dependent on your qualifications and relevant experience in scale 10 (max. € 5.867 gross salary based on a full-time position). Additionally, the UMCG offers an 8% holiday allowance, an 8.3% year-end bonus.The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

More information

For more information please contact:

• Dr. Wia Baron, [e-mail]
• Dr. Susanne Kooistra, [e-mail]
• Prof. dr. Bart Eggen, [e-mail]

Company/Institute University Medical Center Groningen (UMCG) Country Netherlands City Groningen Postal Code 9713 GZ Street Hanzeplein 1