ALS Protein Biology & Pathway Discovery - Postdoc

AcademicTransfer; Nederland; On-site; EUR 40,000 - 47,000; Full time

Job summary

University Medical Center Utrecht (UMC Utrecht) invites applications for a postdoctoral researcher in Neurobiology to study ALS-related proteins and pathways in human tissue and neuronal models. You will apply advanced imaging and molecular techniques to uncover disease mechanisms and biomarkers.

Collaborating with a multidisciplinary team and junior researchers, you will plan experiments, troubleshoot challenges and contribute to high-impact publications.

Qualifications

• PhD in neuroscience or related field.
• Extensive hands-on experience in molecular/cell biology and immunostaining.
• Experience with immunohistochemistry/immunocytochemistry and antibody optimization.
• Ability to design, troubleshoot and interpret experiments; collaborate on goals.
• Strong communication and scientific writing skills; ability to mentor juniors.

Responsibilities

• Investigate ALS tissue using protein-level characterization and neuronal models.
• Establish high-dimensional multiplexed protein imaging with MACSima platform.
• Work with iPSC-derived neurons and collaborators to study gene effects.
• Mentor PhD/MSc students and contribute to publications.
• Collaborate within a multidisciplinary ALS center to advance research objectives.

Skills

Experimental molecular biology

Immunostaining

Fluorescence microscopy

Protein analysis

Immunohistochemistry

Experiment design

Scientific communication

Mentorship

Human brain tissue experience

Multiplexed immunofluorescence

Spatial proteomics

High-dimensional imaging

Image analysis (Fiji/ImageJ/QuPath/CP)

Western blotting

qPCR

iPSC-derived neuronal models

Cytoskeletal biology/microtubules

Single-cell/spatial transcriptomics

Junior researcher mentorship

Education

PhD in neuroscience, molecular/cell biology, neuropathology, biomedical sciences or related field

Tools

Fiji/ImageJ

QuPath

CellProfiler

Job description

University Medical Center Utrecht (UMC Utrecht) invites applications for a postdoctoral researcher in Neurobiology to study ALS-related proteins and pathways in human tissue and neuronal models. You will apply advanced imaging and molecular techniques to uncover disease mechanisms and biomarkers.

Collaborating with a multidisciplinary team and junior researchers, you will plan experiments, troubleshoot challenges and contribute to high-impact publications.