Research Scientist - AD

Piramal Pharma Limited; Ahmedabad District; On-site; INR 900,000 - 1,100,000; Full time

Job summary

Piramal Pharma Solutions seeks a Senior Research Scientist to lead reverse phase preparative HPLC purifications and method development. You will optimize purification strategies, scale up processes, and ensure timely delivery within multi-disciplinary teams.

Responsibilities include operating preparative HPLC systems, analyzing fractions with HPLC/UPLC, LC-MS, and NMR, and preparing technical reports. Collaborative project work across R&D and regulatory teams is essential.

Qualifications

• Experience in reverse phase preparative HPLC purification of APIs and related compounds.
• Design and optimize purification methods for various stationary phases.
• Scale-up and transfer of methods from analytical to preparative scale.
• Interpretation of chromatographic and spectroscopic data to confirm identity and purity.
• Collaborate with R&D, analytical, and regulatory teams to meet project timelines.

Responsibilities

• Perform reverse phase preparative HPLC purification of APIs and related compounds.
• Develop and optimize purification methods across multiple stationary phases.
• Execute preparative purifications from milligram to multi-gram scales.
• Design purification strategies for challenging compounds with solubility or stability issues.
• Operate and maintain preparative HPLC systems and associated equipment.
• Generate purification reports and technical summaries for projects.

Skills

Preparative HPLC purification

Purification method development

Scale-up & transfer

Data interpretation (HPLC/UPLC, LC-MS,

Tools

Waters HPLC

Agilent HPLC

Shimadzu HPLC

Gilson fraction collectors

Job description

Piramal Pharma Solutions Piramal Pharma Solutions is a contract development and manufacturing organization (CDMO), offering end-to-end development and manufacturing solutions across the drug life cycle. We serve our clients through a globally integrated network of facilities in North America, Europe and Asia. This enables us to offer a comprehensive range of services including Drug Discovery Solutions, Process & Pharmaceutical Development services, Clinical Trial Supplies, Commercial supply of APIs and Finished dosage forms. We also offer specialized services like development and manufacture of Highly Potent APIs and Antibody Drug Conjugation. Our capability as an integrated service provider & experience with various technologies enables us to serve Innovator and Generic companies worldwide. For more details, please visit : www.piramalpharmasolutions.com

Job Title

Senior Research Scientist

Job Description

• Perform reverse phase preparative HPLC purification of APIs, intermediates, impurities, degradants, metabolites, and synthetic target compounds.
• Develop and optimize purification methods using C18, C8, Phenyl, Biphenyl, and specialty stationary phases.
• Execute preparative purifications ranging from milligram to multi-gram scale.
• Design and implement purification strategies for challenging compounds with poor solubility, low stability, or complex impurity profiles.
• Maximize purity, recovery, and productivity while maintaining project timelines.
• Method Development and Scale-Up Transfer analytical HPLC/UPLC methods to preparative scale.
• Optimize mobile phase composition, pH, buffers, gradients, flow rates, and loading conditions.
• Conduct loading studies and purification scale-up activities.
• Improve chromatographic resolution and recovery through systematic method optimization.
• Instrument Operation and Maintenance Operate and maintain preparative HPLC systems, fraction collectors, and associated software.
• Work with systems such as Waters, Agilent, Shimadzu, Gilson, Biotage, or equivalent preparative chromatography platforms.
• Perform routine troubleshooting of chromatographic systems and columns.
• Maintain instrument utilization, calibration, and documentation records.
• Fraction Analysis and Characterization Analyze collected fractions using analytical HPLC/UPLC, LC-MS, and NMR techniques.
• Interpret chromatographic and spectroscopic data to confirm compound identity and purity.
• Support impurity identification and structural characterization activities.
• Generate purification reports and technical summaries.
• Project Execution Support pharmaceutical R&D, process development, impurity isolation, forced degradation, and reference standard projects.
• Collaborate with synthetic chemistry, analytical, formulation, and regulatory teams.
• Prioritize multiple projects and ensure timely delivery of purified compounds.
• Participate in client discussions and provide technical recommendations.

Company Overview

Piramal Pharma Limited, offers a portfolio of differentiated products and services through its 17 global development and manufacturing facilities and a global distribution network in over 100 countries. PPL includes Piramal Pharma Solutions (PPS), an integrated Contract Development and Manufacturing Organization; Piramal Critical Care (PCC), a Complex Hospital Generics business; and the India Consumer Healthcare business, selling over-the- counter products. In addition, one of PPL’s associate companies, AbbVie Therapeutics India Private Limited is a JV with AbbVie Inc. and has emerged as one of the market leaders in the ophthalmology therapy area. Further, PPL has a minority investment in Yapan Bio Private Limited. In October 2020, PPL received a 20% strategic growth investment from the Carlyle Group.

PPL provides equal employment opportunities to all employees and applicants for employment. It prohibits discrimination and harassment based on race, color, age, sex, religion, national origin or ethnicity, disability status, genetics, protected veteran status, sexual orientation, gender identity, or expression, or any other characteristic protected by applicable law. Our employment decisions are based on merit considering qualifications, skills, performance, and achievements. Equal employment opportunity applies to all terms and conditions of employment, including recruitment, selection, training, social programs, placement, promotion, demotion, compensation and benefits, transfers, terminations, and working conditions.