Research and Development Executive

Manipal Specialty Chemicals Private Limited; Udupi district; On-site; INR 900,000 - 1,300,000; Full time

Job summary

Manipal Specialty Chemicals Private Limited in India seeks a hands-on R&D professional to develop and optimize chemical processes from lab through pilot and plant scale, ensuring GMP manufacturing practices and successful technology transfer.

You will lead reaction route scouting, optimize parameters, and troubleshoot scale-up issues, supporting purification, isolation, and analytical interpretation to deliver robust processes for pharma and fine chemicals.

Qualifications

• M.Sc. in Organic/Industrial Chemistry or related field with strong synthetic lab exposure.
• 3–4 years of experience in chemical R&D or process development.
• Experience in GMP manufacturing environments and GMP documentation.

Responsibilities

• Develop, optimize, and establish robust chemical processes for pharma, API, specialty chemical, and fine chemical products.
• Perform reaction route scouting, process optimization, and laboratory experimentation.
• Optimize critical process parameters such as temperature, time, reagent/solvent quantity, concentration, pH, addition rate, agitation, and reaction conditions.
• Evaluate process efficiency with respect to yield, purity, selectivity, cycle time, solvent consumption, and scalability.
• Identify and troubleshoot process-related issues during development and scale-up.
• Plan and execute laboratory R&D batches and process optimization experiments.
• Demonstrate successful transition from gram scale to kilogram/pilot scale and plant scale.
• Participate in pilot and commercial manufacturing batches and provide technical support during execution.
• Monitor process performance during scale-up and identify potential scale-dependent issues.
• Support process validation, process improvement, and troubleshooting activities.
• Hands-on experience in various purification and isolation techniques, including crystallization, fractional/vacuum distillation, column chromatography, impurity purge and control strategies.
• Select and optimize suitable purification technology based on product properties, impurity profile, yield, scalability, and commercial feasibility.

Skills

GMP manufacturing

Process optimization

Scale-up expertise

Analytical interpretation

Laboratory experimentation

Documentation

NMR interpretation

Purification techniques

Education

M.Sc. in Organic / Industrial Chemistry

Tools

HPLC

GC

GC-MS

LC-MS

NMR

IR

UV

Melting point analysis

MS Office

Job description

Hands-on experience in R&D, pilot-scale and plant-scale manufacturing batches, with a strong understanding of organic chemistry, reaction optimization, process development, scale-up, purification, analytical interpretation, and GMP manufacturing practices.

The role involves developing and optimizing chemical processes from laboratory scale through pilot/plant scale, troubleshooting process issues, improving yield and purity, and supporting technology transfer and manufacturing activities.

Key Responsibilities:

1. Process & Product Development

• Develop, optimize, and establish robust chemical processes for pharmaceutical, API, specialty chemical, and fine chemical products.
• Perform reaction route scouting, process optimization, and laboratory experimentation.
• Optimize critical process parameters such as temperature, time, reagent/solvent quantity, concentration, pH, addition rate, agitation, and reaction conditions.
• Evaluate process efficiency with respect to yield, purity, selectivity, cycle time, solvent consumption, and scalability.
• Identify and troubleshoot process-related issues during development and scale-up.

2. R&D and Scale-Up Activities:

• Plan and execute laboratory R&D batches and process optimization experiments.
• Demonstrate successful transition from gram scale to kilogram/pilot scale and plant scale.
• Participate in pilot and commercial manufacturing batches and provide technical support during execution.
• Monitor process performance during scale-up and identify potential scale-dependent issues.
• Support process validation, process improvement, and troubleshooting activities.

3. Purification & Isolation:

• Hands-on experience in various purification and isolation techniques, including: Crystallization / precipitation, Fractional / vacuum distillation, Column chromatography, Impurity purge and control strategies
• The candidate should be able to select and optimize suitable purification technology based on product properties, impurity profile, yield, scalability, and commercial feasibility.

Skills Required

• Familiarity with standard organic reactions and laboratory practices.
• Experience in GMP manufacturing environments, GMP documentation and manufacturing practices.
• Good understanding of purification and basic analytical interpretation.
• Good understanding of HPLC, GC, GC-MS, LC-MS, NMR, IR, UV and melting point data.
• Interpret ¹H NMR and ¹³C NMR spectra for structure confirmation and impurity identification.
• Keen attention to detail and eagerness to learn from senior team members.
• Ability to work in a collaborative team environment and handle multiple lab tasks.
• Basic proficiency in using MS Office for documentation and report preparation
• Follow laboratory SOPs, EHS requirements, and chemical handling procedures
• Adhere to safety guidelines and responsible disposal of chemical waste.

Technical/Functional Proficiency Required

• Proven track record of successful scale-up from lab to pilot/plant.
• Strong problem-solving mindset and ability to work in a fast-paced, project-driven environment.

Educational Qualifications

M.Sc. in Organic / Industrial Chemistry or related field with strong synthetic lab exposure.

Experience Level (If applicable)

3–4 years of experience in chemical R&D or process development.