Chemist / Senior Chemist - Oligonucleotide Chemistry : Jubilant Biosys

Jubilant Pharmova; Mysuru; On-site; INR 550,000 - 850,000; Full time

Job summary

Jubilant Pharmova Limited invites a Chemist/Senior Chemist for synthesis, purification, and development of basic oligonucleotide intermediates and phosphoramidites in Karnataka. You will execute scale-up, ensure quality, and document results, working closely with safety and GMP practices.

The role requires 2–8 years of experience, M.Sc. in Organic/Medicinal Chemistry or M.Pharm, and hands-on lab expertise in nucleoside chemistry, chromatography, and characterization techniques.

Qualifications

• M.Sc. Organic Chemistry or Medicinal Chemistry or M.Pharm.
• Industrial experience in oligonucleotide, nucleoside, nucleotide, or phosphoramidite chemistry preferred.
• Laboratory experience from milligram to gram scale.

Responsibilities

• Synthesize nucleoside intermediates and phosphoramidites.
• Execute DMT protection/deprotection, phosphitylation, chromatography.
• Handle moisture-sensitive reagents like phosphoramidites and activators.
• Support oligonucleotide synthesis, cleavage, deprotection and purification.
• Assist process development and optimization for amidites and building blocks.
• Plan and execute reactions from mg to g scale.
• Operate reactors, evaporators, filtration and drying equipment.
• Monitor reactions using TLC, HPLC/UPLC, GC and NMR.
• Maintain GMP-style notebooks and records.

Skills

Oligonucleotide synthesis

Phosphoramidite chemistry

Process development

Laboratory operations

Documentation

Education

M.Sc. Organic/Medicinal Chemistry

M.Pharm

Tools

HPLC

UPLC

NMR

GC

TLC

KF

Job description

Job Description

Position: Chemist / Senior Chemist

Location: Nanjangud / Mysore, Karnataka

Experience: 2-8 Years

Qualification

• M.Sc. (Organic Chemistry / Medicinal Chemistry) or M. Pharm.
• Candidates with industrial experience in basic oligonucleotide, nucleoside, nucleotide, or phosphoramidite chemistry will be preferred.

Job Summary

The Chemist/Senior Chemist will be responsible for the synthesis, purification, characterization, and process development of basic oligonucleotide intermediates, phosphoramidites, nucleosides, and related specialty chemicals. The role involves laboratory execution, process scale-up support, technology transfer, documentation, and adherence to safety and quality requirements.

Key Responsibilities

Oligonucleotide & Phosphoramidite Chemistry

• Synthesize nucleoside intermediates and phosphoramidites.
• Execute DMT protection/deprotection, phosphitylation, and chromatography processes.
• Handle moisture-sensitive reagents such as phosphoramidites, phosphorus chlorides, CEP reagents, and activators.
• Support oligonucleotide synthesis, cleavage, deprotection, and purification activities.
• Assist in process development and optimization for amidites and oligonucleotide building blocks.

Laboratory Operations

• Plan and execute reactions from milligram to gram scale.
• Operate reactors, rotary evaporators, vacuum systems, filtration and drying equipment.
• Perform reaction monitoring using TLC, HPLC, UPLC, GC, KF, and NMR interpretation.
• Maintain laboratory notebooks and experimental records.

Process Development

• Conduct route scouting and process optimization studies.
• Identify critical process parameters and process risks.
• Support technology transfer and scale-up from laboratory to pilot plant/manufacturing.
• Prepare process descriptions, batch records, and development reports.

Documentation & Compliance

• Maintain GMP-compliant documentation where applicable.
• Prepare SOPs, risk assessments, and technical reports.
• Ensure compliance with EHS, quality, and data integrity requirements.