Postdoc: LNP Gene Editing for Neurodegeneration

The University of Hong Kong; Hong Kong; In loco; HKD 360.000 - 480.000; Tempo pieno

Vantaggi offerti da questo lavoro

Annual leave

Medical benefits

Campus gym access

Library access

Descrizione del lavoro

The University of Hong Kong invites applications to join the JC STEM Lab of Nanomedicine for Advanced Therapy in the Department of Pharmacology and Pharmacy. A postdoctoral fellow position focuses on evaluating CRISPR-Cas9 gene editing using lipid nanoparticles to treat neurodegenerative disease models.

The role involves designing and optimizing LNP delivery, conducting in vivo studies, data analysis, manuscript preparation, and supervision of students, with opportunities for grant writing and

Competenze

• Ph.D. in a related field is required.
• Strong track record in gene editing or nanoparticle-based therapeutics.
• Demonstrated experience in scientific writing and publication.

Mansioni

• Design and evaluate CRISPR-Cas9-based gene editing strategies for single and dual gene knockout in disease-relevant models.
• Formulate, characterise and optimise lipid nanoparticles for encapsulation and delivery of gene editing payloads.
• Conduct in vivo animal studies, including administration of LNP-based therapeutics, sample collection, and disease progression monitoring.
• Perform behavioural studies and phenotypic assessments in disease mouse models to evaluate therapeutic efficacy.
• Apply immunohistochemistry to determine tissue- and cell-type-specific targeting and delivery precision.
• Conduct western blot and molecular analyses to quantify target protein knockout and pathological markers.
• Support transcriptomic studies and contribute to computational modelling of molecular interplay.
• Collaborate internationally, prepare reports and protocols, and contribute to grant and manuscript writing.
• Supervise students and disseminate findings through publications and conference presentations.
• Collaborate with other team member to ensure effective synergy between various projects.

Conoscenze

CRISPR-Cas9 design

Lipid nanoparticle formulation

In vivo animal studies

Molecular biology techniques

Scientific writing

Formazione

Ph.D. in Molecular Biology / Biochemistry / Pharmacology / Neuroscience / Bioengineering

Strumenti

CRISPR design software

Immunohistochemistry equipment

Animal handling facilities

Descrizione del lavoro

The University of Hong Kong invites applications to join the JC STEM Lab of Nanomedicine for Advanced Therapy in the Department of Pharmacology and Pharmacy. A postdoctoral fellow position focuses on evaluating CRISPR-Cas9 gene editing using lipid nanoparticles to treat neurodegenerative disease models.

The role involves designing and optimizing LNP delivery, conducting in vivo studies, data analysis, manuscript preparation, and supervision of students, with opportunities for grant writing and