Biotech à United States

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Hlx Life Sciences

london, United Kingdom

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23.05.2025

07.07.2025

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Job Title:

Scientist – Tissue Handling

Employment Type: 12 month Contract

Location: London, UK - 100% Lab based

The Role:

We are seeking a highly motivated Scientist / Recent Ph.D Graduate with a background in Molecular Biology, Cell Biology, or a related field. The ideal candidate will have experience in spatial transcriptomics and proteomics, particularly using FFPE tissue samples, and a strong background in 10X Genomics library preparation for NGS.

You’ll work in a fast-paced, collaborative environment, driving the development and optimization of cutting-edge spatial omics workflows in support of translational research and clinical discovery.

Key Responsibilities:

• Design, execute, and troubleshoot experiments using 10X Genomics Visium and related platforms for spatial transcriptomics.
• Process and analyze FFPE and fresh frozen tissue samples for transcriptomic and proteomic profiling.
• Prepare high-quality NGS libraries for Illumina sequencing, ensuring data integrity and reproducibility.
• Optimize protocols and workflows for challenging tissues (e.g., fibrotic, adipose, cartilage, bone).
• Collaborate with bioinformaticians, pathologists, and clinical researchers to interpret spatial omics data.
• Maintain accurate records, contribute to publications, and present findings at internal and external meetings.

Required Qualifications:

• Ph.D. in Molecular Biology, Cell Biology, Biotechnology, or related discipline with a focus on spatial transcriptomics or proteomics.
• Proven experience handling FFPE tissues for transcriptomic and protein-based methods.
• Expertise in 10X Genomics library preparation and workflows for NGS (e.g., Chromium, Visium).
• Familiarity with Illumina sequencing platforms and general NGS QC metrics.
• Experience working with difficult tissue types such as fibrotic, adipose, cartilage, or bone.
• Hands-on experience in single-cell technologies (e.g., scRNA-seq, CITE-seq) is a strong plus.

Preferred Skills:

• Strong understanding of tissue processing, histology, and immunostaining techniques.
• Excellent organizational and communication skills.
• Ability to work both independently and within cross-functional teams.

What We Offer:

• Competitive salary and benefits package.
• Access to state-of-the-art facilities and research platforms.
• Opportunities for professional development and international collaboration.
• A dynamic and inclusive working environment that supports innovation and curiosity.