Senior Translational Pharmacology Scientist – Hybrid

Isomorphic Labs; Greater London; Hybrid; GBP 90,000 - 130,000; Full time

Benefits offered by this job

Hybrid working model

Office in London 3 days a week

Job summary

Isomorphic Labs in London is seeking a Senior Drug Discovery Biologist to drive translational biology for Healthspan-focused programs. You will design screening cascades, lead biology across hit to lead and candidate selection, and collaborate with AI/ML, CROs, and external partners to deliver clinically relevant data.

You will develop biomarkers, oversee assay development, and contribute to IND/CTA preparations while working with multidisciplinary teams across discovery biology and chemistry.

Qualifications

• BSc, MSc, or PhD in Pharmacology, Cellular/Molecular Biology, Physiology, Neuroscience, or a relevant field.
• Hands-on and strategic pharmaceutical/biotech experience in designing biological screening cascades.
• Deep knowledge of in‑vitro pharmacology techniques across biophysical, biochemical and cellular assays.
• Understanding of translational models for maximised Healthspan and Target Product Profiles (TPPs).
• Experience in leading biology within drug discovery programs and contributing to Clinical Candidate delivery.

Responsibilities

• Design and implement efficient, fit-for-purpose biological screening cascades for drug design programs from Hit Identification to Candidate Selection.
• Provide deep technical and strategic expertise across biochemical, biophysical, and cellular assays to characterize MoA, potency, selectivity, and SAR.
• Define translational model paradigms for each project’s package and develop biomarker strategies for early clinical proof of concept.
• Collaborate with CROs and external partners to design critical experiments and ensure high-quality data for clinic progression.
• Work with business development to assess collaboration opportunities and with external teams to progress programs.
• Support AI/ML teams with experimental data and bidirectional feedback to refine models of biological systems.
• Contribute to internal nomination packages and supporting regulatory documentation (IND/CTA) as needed.

Skills

In vitro pharmacology

Translational biology

MOA & SAR analysis

TPP knowledge

CRO management

Team collaboration

AI/ML collaboration

Education

BSc, MSc, or PhD in Pharmacology, Cellular/Molecular Biology, Physiology, Neuroscience, or a relevant field of biology.

Tools

ELISA

HTRF

nanoBRET

High Content Screening

Job description

Isomorphic Labs in London is seeking a Senior Drug Discovery Biologist to drive translational biology for Healthspan-focused programs. You will design screening cascades, lead biology across hit to lead and candidate selection, and collaborate with AI/ML, CROs, and external partners to deliver clinically relevant data.

You will develop biomarkers, oversee assay development, and contribute to IND/CTA preparations while working with multidisciplinary teams across discovery biology and chemistry.