Senior Biologics Computational Scientist (Hybrid)

Data Science Jobs UK; Greater London; Hybrid; GBP 110,000 - 150,000; Full time

Job summary

Isomorphic Labs is seeking a Senior Research Investigator (Biologics Computational Science) in London. You will design novel biologics using cutting-edge AI drug design engines, collaborating with ML and biology teams across discovery stages to drive candidate selection toward the clinic.

The role requires a PhD and a strong track record in computational biology, with hands-on Python and experience predicting properties such as affinity and developability. Hybrid work is available.

Qualifications

• PhD or equivalent in computer science, computational biology, structural biology, biochemistry or related field.
• Experience using ML methods to predict biologics properties from sequence (affinity, developability, immunogenicity).
• Proficient programming with Python and scientific computing stacks.
• Experience preparing datasets, benchmarking models, and working with structure-based metrics.
• Able to adapt to fast-changing environments and cross-disciplinary collaboration.
• Strong publication or research track record in computational biology or drug design.

Responsibilities

• Identify opportunities for computational modelling to enhance biologics discovery programs.
• Collaborate with ML and biologics teams to develop methods predicting biologics properties from sequence.
• Apply computational methods to discover novel therapeutics.
• Benchmark existing computational methods and develop baseline models.
• Analyse data from lab experiments to inform decisions in biologics discovery.
• Determine data to generate to improve ML models and implement active learning strategies.
• Develop methods for predicting functional properties of biologics.

Skills

ML for biologics

Predict biologics properties

Python

Datasets & benchmarking

Adaptable

Education

PhD in related field (CS / computational biology / structural biology / biochemistry)

Job description

Isomorphic Labs is seeking a Senior Research Investigator (Biologics Computational Science) in London. You will design novel biologics using cutting-edge AI drug design engines, collaborating with ML and biology teams across discovery stages to drive candidate selection toward the clinic.

The role requires a PhD and a strong track record in computational biology, with hands-on Python and experience predicting properties such as affinity and developability. Hybrid work is available.