Hybrid In Vitro Pharmacology Leader

Isomorphic Labs; Cambridge; Hybrid; GBP 85,000 - 110,000; Full time

Benefits offered by this job

Hybrid work model

Job summary

Isomorphic Labs in Cambridge is seeking a Research Leader / Senior Scientist in Translational Sciences to lead in vitro pharmacology efforts within small molecule drug discovery. You will define screening cascades, guide assays, and collaborate with AI/ML, medicinal chemistry, and structural biology teams to advance targets toward clinical candidates.

The role includes line management for a 2–3 person team, mentoring and fostering a cross-disciplinary culture, and coordinating with CROs to

Qualifications

• Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or a related scientific discipline.
• 8+ years / 5+ years of professional experience in a Translational Sciences role, in biotech, pharma or CRO.
• Experience leading biology within small molecule drug discovery programs, from inception to clinical candidate delivery.
• People management experience leading a high-performing scientific team.
• Extensive experience designing and implementing biological screening cascades for drug design projects.
• Deep knowledge of in vitro pharmacology techniques including biophysical, biochemical and/or cellular assays.
• Ability to guide cross-functional programs and collaborate with CROs to deliver high-quality data.

Responsibilities

• Design efficient and comprehensive biological screening cascades for internal and partnered drug design programs.
• Guide the optimization and implementation of biophysical and biochemical assays (SPR, ITC, enzymatic) to evaluate binding, potency and specificity.
• Direct the development of functional and phenotypic cellular assays to advance target validation and mechanistic understanding.
• Collaborate with CROs to design decision-making experiments and deliver high-quality data for IND-enabling packages.
• Interpret binding, kinetic and dose-response data; generate precise documentation to guide strategic decisions.
• Bridge computational predictions with experimental data, coordinating with AI/ML, medicinal chemistry, structural biology, and translational sciences teams.

Skills

In vitro pharmacology

Biophysical assays

Biochemical assays

Cell-based assays

Project leadership

CRO management

Cross-functional collaboration

Scientific communication

Education

Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or related

Tools

SPR

ITC

Job description

Isomorphic Labs in Cambridge is seeking a Research Leader / Senior Scientist in Translational Sciences to lead in vitro pharmacology efforts within small molecule drug discovery. You will define screening cascades, guide assays, and collaborate with AI/ML, medicinal chemistry, and structural biology teams to advance targets toward clinical candidates.

The role includes line management for a 2–3 person team, mentoring and fostering a cross-disciplinary culture, and coordinating with CROs to