Senior Scientist (Process Development)

The Scarlet; Bath; On-site; GBP 55,000 - 85,000; Full time

Job summary

Scarlet Therapeutics is seeking a senior scientist to lead cell culture and process development for donor‑derived erythroid lines. You will maintain equipment, perform risk assessments, and work to uphold GMP quality standards.

The role requires collaboration with researchers, training teammates, and contributing to SOP development. You will apply molecular biology techniques (PCR/qPCR, cloning, viral transduction) and operate bioreactors with downstream filtration.

Qualifications

• Minimum of 5 years' experience in mammalian cell culture and process development (upstream and downstream).
• Familiarity with GMP standards and quality systems.
• Experience with high‑throughput screening and automation is highly desirable.
• Proficiency in molecular biology techniques (PCR, qPCR, cloning, transduction, and transfection).
• Strong written and verbal communication skills.

Responsibilities

• Maintain and calibrate all laboratory equipment in accordance with company standards.
• Conduct risk assessments for all laboratory activities and implement mitigation strategies.
• Characterise donor‑derived erythroid cell lines using cell biology and molecular biology methods.
• Support and train other scientists, providing expert input into method development.
• Review and update laboratory SOPs to align with quality standards.

Skills

Mammalian cell culture

Process development

GMP experience

High‑throughput screening

Automation

Data analysis

Molecular biology techniques

Flow cytometry

PCR/qPCR

Tools

Bioreactors

Downstream filtration systems

PCR/qPCR equipment

Viral transduction equipment

Job description

produced cell lines.Ensure that all Equipment is properly maintained and calibrated for use and maintained in accordance with company standards. Conduct risk assessments for all laboratory activities, identifying potential issues and implementing mitigation strategies to ensure product quality and safety. Characterisation of donor derived erythroid cell lines using various cell biology and molecular biology techniques.Help support and train other scientists and provide experienced user input into the development and improvement of such processes.Stay updated on the latest advancements in mammalian cell line research and integrate new methodologies and technologies when applicable. Regularly review and update laboratory SOPs (Standard Operating Procedures) to ensure alignment with appropriate quality standards. Generally adhere to applicable policies and procedure relating to working in the laboratory including adherence to documentation of activities in electronic laboratory notebooks Key

requirements:

• Minimum of 5 years' experience in mammalian cell culture and process development (upstream and downstream), mostly gained within a Biotechnology/Pharmaceutical setting.
• Familiarity with laboratory scale bioreactors and downstream filtration systems.
• Familiarity with analytical techniques related to cell culture, such as flow cytometry, ELISA, Western blotting.
• Excellent problem-solving and analytical skills.
• Strong verbal and written communication skills.
• Preferred Experience:Strong understanding and experience of operating to a GMP standard.
• Familiarity with high-throughput screening methods and use of automation.
• Analysis of proteomic, lipidomic and metabolic data.
• Proficiency in molecular biology techniques such as PCR, qPCR, cloning, viral transduction and transfection.

Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.

To qualify for this position, you will need to be authorized to live and work in the UK.