Senior Scientist (Process Development)

The Scarlet; Bradley Stoke; On-site; GBP 65,000 - 85,000; Full time

Job summary

The Scarlet is seeking an experienced scientist to advance mammalian cell culture and process development, including upstream and downstream operations. You will characterise donor-derived cell lines, assist in method development, and train colleagues while maintaining GMP-aligned practices.

Responsibilities include equipment maintenance, risk assessments, SOP updates, and documentation in ELN. Authors will stay current with advancements in cell line research and adopt new methods as applicable.

Qualifications

• Minimum 5 years' experience in mammalian cell culture and process development (upstream and downstream)
• Familiarity with laboratory scale bioreactors and downstream filtration systems
• Familiarity with analytical techniques related to cell culture, such as flow cytometry, ELISA, Western blotting
• Excellent problem-solving and analytical skills
• Strong verbal and written communication skills
• Preferred Experience: Strong understanding and experience of operating to a GMP standard
• Familiarity with high-throughput screening methods and use of automation
• Analysis of proteomic, lipidomic and metabolic data
• Proficiency in molecular biology techniques such as PCR, qPCR, cloning, viral transduction and transfection

Responsibilities

• Maintain and calibrate laboratory equipment according to company standards
• Conduct risk assessments for laboratory activities and implement mitigation strategies
• Characterise donor-derived erythroid cell lines using cell biology and molecular biology techniques
• Support and train other scientists and contribute to process development improvements
• Stay updated on mammalian cell line research and adopt new methodologies when applicable
• Regularly review and update laboratory SOPs to align with quality standards
• Ensure compliance with laboratory policies and proper documentation in electronic notebooks (ELN)

Skills

Mammalian cell culture

Upstream and downstream processing

Flow cytometry

ELISA

Western blotting

GMP experience

High-throughput screening

Automation

Molecular biology techniques

Tools

Bioreactors

Downstream filtration

Job description

produced cell lines.Ensure that all Equipment is properly maintained and calibrated for use and maintained in accordance with company standards. Conduct risk assessments for all laboratory activities, identifying potential issues and implementing mitigation strategies to ensure product quality and safety. Characterisation of donor derived erythroid cell lines using various cell biology and molecular biology techniques.Help support and train other scientists and provide experienced user input into the development and improvement of such processes.Stay updated on the latest advancements in mammalian cell line research and integrate new methodologies and technologies when applicable. Regularly review and update laboratory SOPs (Standard Operating Procedures) to ensure alignment with appropriate quality standards. Generally adhere to applicable policies and procedure relating to working in the laboratory including adherence to documentation of activities in electronic laboratory notebooks Key

requirements:

• Minimum of 5 years' experience in mammalian cell culture and process development (upstream and downstream), mostly gained within a Biotechnology/Pharmaceutical setting.
• Familiarity with laboratory scale bioreactors and downstream filtration systems.
• Familiarity with analytical techniques related to cell culture, such as flow cytometry, ELISA, Western blotting.
• Excellent problem-solving and analytical skills.
• Strong verbal and written communication skills.
• Preferred Experience:Strong understanding and experience of operating to a GMP standard.
• Familiarity with high-throughput screening methods and use of automation.
• Analysis of proteomic, lipidomic and metabolic data.
• Proficiency in molecular biology techniques such as PCR, qPCR, cloning, viral transduction and transfection.

Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.

To qualify for this position, you will need to be authorized to live and work in the UK.