Senior Process Development Scientist - Red Blood Cells

Scarlet Therapeutics Ltd; West of England; On-site; GBP 65,000 - 90,000; Full time

Job summary

Scarlet Therapeutics seeks a Senior Process Development Scientist to lead manufacturing process development for its red blood cell–based therapeutics. You will generate mammalian cell culture processes and develop new cell lines, with a focus on upstream and downstream operations.

The role emphasizes developing formulations, documenting with quality systems, and mentoring peers to advance innovative therapeutics in a Bristol-based team.

Qualifications

• Minimum 5 years of mammalian cell culture and process development experience.
• Experience with GMP environments preferred.
• Familiarity with bioreactors and downstream filtration systems.
• Knowledge of analytical techniques for cell culture.

Responsibilities

• Invent, develop and optimize mammalian cell culture processes for cell lines.
• Develop formulations to stabilise red cell therapeutics.
• Document work to support regulatory submissions and IP.
• Implement quality controls to monitor cell line integrity and contamination.
• Maintain and calibrate lab equipment per company standards.
• Prepare risk assessments and mitigation strategies for lab activities.
• Characterise donor-derived erythroid lines using molecular biology techniques.
• Train and mentor other scientists and share process improvements.
• Stay updated on advancements and integrate new methods as applicable.
• Regularly review laboratory SOPs to align with quality standards.

Skills

Mammalian cell culture

Process development

Upstream/downstream

Analytical techniques

Problem solving

Communication skills

Tools

Flow cytometry

ELISA

Western blotting

Job description

Scarlet Therapeutics seeks a Senior Process Development Scientist to lead manufacturing process development for its red blood cell–based therapeutics. You will generate mammalian cell culture processes and develop new cell lines, with a focus on upstream and downstream operations.

The role emphasizes developing formulations, documenting with quality systems, and mentoring peers to advance innovative therapeutics in a Bristol-based team.