Senior Scientist (Process Development)

The Scarlet; West of England; On-site; GBP 60,000 - 90,000; Full time

Job summary

Scarlet Therapeutics is seeking a senior scientist to drive mammalian cell culture and process development in a GMP environment. You will maintain equipment, run risk assessments, and characterize donor-derived erythroid cell lines using diverse cell biology and molecular biology techniques.

You will also support colleagues, stay abreast of trends, review SOPs, and contribute to continuous improvement while applying advanced analytical methods and clear communication.

Qualifications

• 5+ years' experience in mammalian cell culture and process development (upstream and downstream) in biotech/pharma.
• Familiarity with laboratory-scale bioreactors and downstream filtration systems.
• Familiarity with analytical techniques: flow cytometry, ELISA, Western blotting.
• Excellent problem-solving and analytical skills.
• Strong verbal and written communication skills.
• Preferred: GMP standard experience.
• Familiarity with high-throughput screening and automation.
• Analysis of proteomic, lipidomic and metabolic data.
• Proficiency in molecular biology techniques: PCR, qPCR, cloning, viral transduction and transfection.

Responsibilities

• Maintain and calibrate equipment per company standards.
• Conduct risk assessments for all laboratory activities.
• Characterise donor derived erythroid cell lines using cell biology and molecular biology techniques.
• Support and train other scientists; provide input into development of processes.
• Stay updated on advancements and integrate new methodologies.
• Review and update laboratory SOPs to align with quality standards.
• Adhere to policies and ensure documentation in electronic notebooks.

Skills

Mammalian cell culture

Process development

GMP experience

High-throughput screening

Automation

Data analysis

Analytical techniques

Communication skills

Problem-solving

PCR/qPCR

Tools

Bioreactors

Filtration systems

qPCR

Job description

produced cell lines.Ensure that all Equipment is properly maintained and calibrated for use and maintained in accordance with company standards. Conduct risk assessments for all laboratory activities, identifying potential issues and implementing mitigation strategies to ensure product quality and safety. Characterisation of donor derived erythroid cell lines using various cell biology and molecular biology techniques.Help support and train other scientists and provide experienced user input into the development and improvement of such processes.Stay updated on the latest advancements in mammalian cell line research and integrate new methodologies and technologies when applicable. Regularly review and update laboratory SOPs (Standard Operating Procedures) to ensure alignment with appropriate quality standards. Generally adhere to applicable policies and procedure relating to working in the laboratory including adherence to documentation of activities in electronic laboratory notebooks Key

requirements:

• Minimum of 5 years' experience in mammalian cell culture and process development (upstream and downstream), mostly gained within a Biotechnology/Pharmaceutical setting.
• Familiarity with laboratory scale bioreactors and downstream filtration systems.
• Familiarity with analytical techniques related to cell culture, such as flow cytometry, ELISA, Western blotting.
• Excellent problem-solving and analytical skills.
• Strong verbal and written communication skills.
• Preferred Experience:Strong understanding and experience of operating to a GMP standard.
• Familiarity with high-throughput screening methods and use of automation.
• Analysis of proteomic, lipidomic and metabolic data.
• Proficiency in molecular biology techniques such as PCR, qPCR, cloning, viral transduction and transfection.

Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.

To qualify for this position, you will need to be authorized to live and work in the UK.