Senior Scientist – Gene Editing (Bioprocessing R&D)

Revvity, Inc.; Cambridge; On-site; GBP 55,000 - 85,000; Full time

Job summary

Revvity's Bioprocessing R&D team seeks a Senior Scientist to execute gene editing projects in mammalian bioproduction cell lines for client projects, designing KO and KI strategies and contributing to cell line development.

The role requires strong molecular biology skills, experience with cloning (Gibson, Golden Gate), PCR/qPCR/ddPCR, and ability to work independently within defined timelines; collaboration across teams and meticulous documentation.

Qualifications

• Hands-on gene editing in mammalian cells.
• Ability to design KO and KI experiments.
• Strong molecular biology and cloning skills.
• Experience delivering within defined project timelines.
• Excellent written and verbal communication.

Responsibilities

• Design and execute gene editing strategies for KO and KI in mammalian bioproduction cell lines.
• Independently manage assigned project workstreams and communicate with internal teams.
• Analyze and interpret experimental data and propose next steps.
• Maintain accurate laboratory records and SOPs.
• Collaborate across Bioprocessing and wider organization to support delivery.
• Contribute to cell line development activities for expressing lines.

Skills

Gene editing

KO/KI design

Mammalian cell culture

Experiment design

Data analysis

Scientific communication

Independent work

Education

MSc/PhD or equivalent

Tools

Gibson Assembly

Golden Gate Assembly

PCR

qPCR

ddPCR

Job description

Revvity's Bioprocessing department is at the forefront of developing advanced expression platforms to enable the manufacturing of next-generation biotherapeutics. We offer a diverse portfolio of mammalian host cell lines and innovative expression technologies designed for rapid identification of high-expressing recombinant clones. Leveraging extensive expertise in gene editing and cell line engineering, we deliver custom solutions tailored to our clients' unique manufacturing needs, for both protein and viral vector therapeutics.

Job Summary

As a Senior Scientist in the Bioprocessing R&D team, you will be primarily responsible for executing gene editing projects in mammalian bioproduction cell lines on behalf of clients, applying your expertise to design and implement targeted knockout (KO) and knock-in (KI) strategies. Working to defined project timelines and client requirements, you will bring strong technical independence and a delivery-focused mindset to ensure high-quality outcomes. In addition to gene editing, you may also contribute to cell line development projects supporting the generation of expressing mammalian cell lines, broadening the scope of your impact within the team. This is a hands-on, lab-based role suited to a scientist who thrives in a client-project environment, is comfortable working independently to deadlines, and brings a rigorous and methodical approach to experimental design and execution.

Key Responsibilities

• Design and execute gene editing strategies for KO and KI applications in mammalian bioproduction cell lines, planning and troubleshooting experiments to deliver high-quality, reproducible outcomes within agreed project timelines.
• Independently manage assigned project workstreams, ensuring timely delivery and maintaining clear communication with internal project teams.
• Analyze and interpret experimental data, drawing well-reasoned conclusions and proposing appropriate next steps.
• Maintain accurate and up-to-date laboratory records, including laboratory notebooks and relevant technical documentation such as SOPs and experimental reports.
• Communicate scientific results clearly and concisely in internal project meetings and written reports.
• Collaborate effectively with colleagues across the Bioprocessing team and wider organization to support project delivery.
• Where required, contribute to cell line development activities supporting the generation of expressing mammalian cell lines for client projects.

Essential Competencies & Requirements

• MSc with PhD or equivalent experience in a relevant scientific discipline (Life Sciences, Biochemical Engineering, or closely related field).
• Demonstrated, hands-on expertise in gene editing with a strong track record of designing and executing KO and KI strategies in mammalian cell lines.
• Solid molecular biology skills, including proficiency in cloning techniques (e.g., Gibson Assembly, Golden Gate Assembly), PCR, qPCR, and ddPCR.
• Proven ability to work independently, manage priorities effectively, and deliver results within defined project timelines.
• Strong experimental design and data analysis skills
• Highly organized, detail-oriented, and committed to producing reliable, reproducible scientific results.
• Excellent written and verbal communication skills, with the ability to present data clearly to internal stakeholders.
• Collaborative team player with a proactive and solution-focused approach.

Desirable Competencies & Requirements

• Experience in CHO cell line development and/or generation of expressing recombinant cell lines (stable pools and/or clones).
• Prior experience working in a client-facing or service-oriented research environment.
• Experience working in GLP or cGMP environments or a strong quality mindset aligned to regulated processes.