Senior Scientist - Analytical Development, Protein Sciences

T-Therapeutics Ltd; Cambridge; On-site; GBP 45,000 - 70,000; Full time

Job summary

A biotechnology company in Cambridge is seeking a Senior Scientist in Analytical Development to lead mass spectrometry-based methods for protein characterization. This role requires a PhD in analytical chemistry or a related field, with extensive experience in mass spectrometry and analytical method development. The ideal candidate will oversee outsourced methods and validate procedures for regulatory submissions, while collaborating within teams and mentoring junior scientists. This position offers the opportunity to contribute to innovative biologics programs in a dynamic environment.

Qualifications

• PhD with industry experience in analytical chemistry, biochemistry, or related field.
• Hands-on experience with mass spectrometry techniques (LC-MS, QTOF, Orbitrap).
• Strong experience with analytical methods for protein characterisation.
• Proven record of leading method development.
• Experience in characterisation of complex biologics.

Responsibilities

• Lead the development of mass spectrometry-based methods for protein characterisation.
• Oversee the development of HPLC/UPLC-based methods.
• Provide technical oversight of outsourced analytical methods.
• Interpret, document, and present data to cross-functional teams.
• Collaborate within CMC and mentor junior colleagues.

Skills

Mass Spectrometry (LC-MS/MS)

HPLC/UPLC techniques

Analytical method development

Data analysis software

Problem-solving skills

Education

PhD in analytical chemistry, biochemistry or related field

Tools

MassLynx

Waters connect

Empower

Job description

T-Therapeutics is a next-generation T cell receptor (TCR) company spun out from the University of Cambridge. The company was created to harness the power of T cell biology, to create safe and effective treatments for cancer and autoimmune disease. T-Therapeutics’ experienced team combines world-leading expertise in mouse genome engineering, single cell genomics, biopharmaceutical drug development, machine-learning and structural biology, anchored in a culture of creativity and collaboration.T-Therapeutics is developing ‘optimal’ TCR therapeutics using its proprietary OpTiMus® discovery platform, that provides an almost unlimited source of unique, antigen‑specific human TCRs. The company is developing a pipeline of first‑in‑class drugs that are intended to become transformative medicines, reshaping the clinical landscape for patients with cancer or autoimmune diseases.

About the Opportunity

We are seeking an experienced, highly motivated Senior Scientist – Analytical Development to join our Protein Sciences Team. The ideal candidate will bring extensive expertise in Mass Spectrometry (LC‑MS/MS) for protein characterisation and a strong background in developing and implementing analytical methods to support the advancement of pre‑clinical biologics programmes.

This role will lead the development of mass spectrometry‑based methods and as well as other characterisation assays for biologics, while also overseeing outsourced methods development and phase appropriate validation to support regulatory submissions.

In this role you will be responsible for:

• Development, optimisation and troubleshooting of analytical methods focused on mass spectrometry for protein characterisation (including intact mass analysis, peptide mapping and glycosylation analysis).
• Development and optimisation of HPLC/UPLC-based methods, including HIC, HILIC, SEC and reverse‑phase chromatography.
• Leading developability and characterisation studies to support pre‑clinical and early development programmes.
• Providing technical oversight of development and validation of outsourced analytical methods in support of future IND/BLA submissions.
• Interpretation, documenting, and presenting data and findings to cross‑functional teams and stakeholders.
• Collaborating within CMC and across multiple teams within the company.
• Mentoring to junior colleagues and encouraging development of additional Mass Spectrometry users or system owners.

Qualifications and requirements:

• imateelf degree (PhD with industry experience) in analytical chemistry, biochemistry or a related field is desired.
• Hands‑on experiencelern with mass spectrometry (e.g. LC‑MS, QTOF, Orbitrap) and HPLC/UPLC techniques.
• Strong experience with a range of analytical methods for protein characterisation such as liquid chromatography (e.g. RP, SEC, HIC), capillary electrophoresis would be an advantage.
• Proficiency in data analysis software (e.g. MassLynx, Waters connect, Empower).
• Proven record of leading method development is essential.
• Experience in characterisation of complex biologics is essential.
• Deep understanding of ICH guidelines and experience with IND/BLA submissions would be an advantage.
ręmy> Ability to work independently and as part of a team.
• Strong analytical and problem‑solving skills.

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