Senior DMPK Scientist – Oxford (Discovery)

BioUK Ltd.; Oxford; On-site; GBP 70,000 - 100,000; Full time

Benefits offered by this job

Health cashback scheme

Life Assurance

Employee equity scheme

25 days annual leave

Pension scheme 6%

Learning and Development

Job summary

OMass Therapeutics, based in Oxford, seeks an experienced DMPK expert to drive discovery to development, delivering high-quality candidate molecules. You will work in a dynamic, collaborative environment with a focus on novel medicines and patient impact.

You will lead DMPK strategies across Hit-to-Lead, Lead Optimisation and Candidate Selection, working with Medicinal Chemistry, Pharmacology and Bioscience teams to overcome challenges and advance programmes.

Qualifications

• Degree or PhD in Biology, Chemistry, Pharmacy, Pharmacokinetics or related pharmaceutical science.
• Significant pharma/biotech/CRO experience with DMPK from early discovery to pre-clinical/first in human.
• Strong knowledge of DMPK including in vitro ADME, in silico ADME and bioanalysis.
• Experience overseeing assay work with CROs or internal laboratories, including protocol design and data interpretation.
• Technical expertise and proven application of in vivo PK modelling, IVIVE and human dose prediction in support of drug discovery and development.

Responsibilities

• Provide DMPK expertise to support a range of drug discovery projects across Hit-to-Lead, Lead Optimisation and Candidate Selection.
• Work with Medicinal Chemistry, Pharmacology and Bioscience colleagues to resolve DMPK challenges in design and optimisation of drug discovery molecules.
• Design, commission and oversee experimental studies to support compound optimisation, project progression and candidate selection to understand and resolve project ADME challenges through CROs.
• Translate in vitro ADME data and pre-clinical PK to prediction of PK and safety in patients.
• Develop mechanistic and PK/PD models to evaluate hypotheses, optimise study design, and support project progression.
• Interpret data and write and present project reports.
• Share information openly and work collaboratively with other departments to advance projects and company goals.
• Represent DMPK on multidisciplinary projects and provide scientific leadership with fresh perspective.

Skills

DMPK science

In vitro ADME

In silico ADME

Bioanalysis

PK modelling

IVIVE

Dose prediction

Analytical thinking

Collaboration

Communication

Education

PhD in Biology

PhD in Chemistry

PhD in Pharmacokinetics

Job description

OMass Therapeutics, based in Oxford, seeks an experienced DMPK expert to drive discovery to development, delivering high-quality candidate molecules. You will work in a dynamic, collaborative environment with a focus on novel medicines and patient impact.

You will lead DMPK strategies across Hit-to-Lead, Lead Optimisation and Candidate Selection, working with Medicinal Chemistry, Pharmacology and Bioscience teams to overcome challenges and advance programmes.