Discovery DMPK Scientist (Senior Scientist II / Principal Scientist)

OMass Therapeutics; Oxford; On-site; GBP 70,000 - 100,000; Full time

Benefits offered by this job

Private Health Insurance

Life Assurance and Income Protection

25 days annual leave + bank holidays

Pension scheme with employer contrib.

Learning and Development Opportunities

Job summary

OMass Therapeutics seeks a Discovery DMPK Scientist (Senior Scientist II / Principal Scientist) to advance drug discovery in Oxford. You will apply DMPK expertise to Hit-to-Lead, Lead Optimisation and Candidate Selection, working closely with Medicinal Chemistry, Pharmacology and Bioscience to resolve PK/ADME challenges.

You will design and oversee experiments, translate in vitro ADME data to PK predictions, and develop mechanistic PK/PD models to inform go/no-go decisions while contributing to

Qualifications

• PhD or equivalent with strong DMPK expertise and experience across early discovery to pre-clinical/first-in-human
• Significant pharma/biotech CRO experience with DMPK input to project teams
• Proven ability to supervise assay work with CROs or in-house labs and interpret data
• Experience building mechanistic PK/PD models to support decision-making
• Excellent communication and collaborative team-working skills

Responsibilities

• Provide DMPK expertise to support Hit-to-Lead, Lead Optimisation and Candidate Selection projects
• Collaborate with Medicinal Chemistry, Pharmacology and Bioscience to resolve DMPK challenges
• Design and oversee experimental studies for compound optimisation and project progression
• Translate in vitro ADME data to PK and safety predictions in patients
• Develop mechanistic PK/PD models to evaluate hypotheses and support study design
• Lead and communicate project progress across teams and stakeholders
• Uphold values of Ambitious, Responsible, Innovative, Focused, Caring and Collaborative

Skills

DMPK knowledge

Analytical skills

Communication skills

Team collaboration

Problem solving

Education

PhD in biology/chemistry/pharmacology

Bachelor's degree in biology/chemistry/pharmacology

Tools

PKPD modelling

In vitro ADME

Job description

OMass Therapeutics is a biotechnology company based in Oxford discovering medicines against highly- validated target ecosystems, such as membrane proteins or intracellular complexes. The company’s unique OdyssION™ technology platform comprises novel biochemistry techniques, next-generation native mass spectrometry, and custom chemistry. OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, that target solute carriers, complex-bound proteins, and GPCRs.

We are seeking a Discovery DMPK Scientist (Senior Scientist II / Principal Scientist depending on experience). You will be part of a dynamic and innovative environment and will become an integral part of our vision to address patients’ unmet needs while building Britain’s Biggest Biotech. You will use your DMPK expertise and scientific curiosity to solve drug discovery challenges, as part of multi-disciplinary project teams. You will be able to work in state-of-the-art laboratory and modern facilities for optimum collaboration alongside a focused and caring team.

You will already have high degree of DMPK knowledge and be passionate about applying these skills to the discovery of novel medicines. You will have a track record of scientific achievement in DMPK science and of working with drug discovery teams to deliver high-quality candidate molecules into development.

To find out more about the meaningful work OMass delivers, as well as gain an understanding of our culture, benefits, and values, visit our website https://www.omass.com/

Essential Experience, Skills, and Qualities

• Degree or PhD in Biology, Chemistry, Pharmacy, Pharmacokinetics or related pharmaceutical science
• Significant amount of relevant pharmaceutical industry, biotech and/or CRO experience with a track record of contributing DMPK expertise from early discovery to pre-clinical / first in human
• A strong knowledge of DMPK science, including in vitro ADME, in silico ADME and bioanalysis
• Experience overseeing assay work with CROs or internal laboratories, including protocol design and data interpretation
• Technical expertise and proven application of in vivo PK modelling, IVIVE and human dose prediction in support of drug discovery and development
• High level of analytical and problem-solving skills, and the ability for lateral thinking
• Caring and inclusive; respectful and receptive to others’ diverse ideas, experience and perspectives, and enjoys working collaboratively with others as a team
• Excellent communication skills, both written and verbal, with a high attention to detail

Preferred Experience and Skills

• Ability to navigate and work effectively in a fast-paced, matrix-team work environment

• Expertise and proven application of PKPD methods and concepts in support of drug discovery
• Experience in managing and working with external contract research organisations
• Excellent understanding of disciplines relevant to drug discovery such as target validation and pharmacology, with experience in early development such as drug safety/toxicology and pharmaceutics
• A creative and strategic thinker who can enthuse the DMPK group and wider OMass team with innovative ideas
• Strong organisational skills with an ability to prioritise work accordingly to project goals and take responsibility for the timely delivery of objectives

Role Responsibilities

• Provide DMPK expertise to support a range of drug discovery projects working across Hit-to-Lead, Lead Optimisation and Candidate Selection
• Work with Medicinal Chemistry, Pharmacology and Bioscience colleagues to resolve or risk-mitigate project-related DMPK challenges in the design and optimisation of drug discovery molecules
• Design, commission and oversee appropriate experimental studies to support compound optimisation, project progression and candidate selection to understand and resolve project ADME challenges through specialist contract research organisations
• Translation from in vitro ADME data and pre-clinical PK to prediction of PK and safety in patients
• Develop mechanistic and PK/PD models to evaluate hypotheses, optimise study design, and support project progression
• Interpret data and write and present project reportsShare information openly and work collaboratively with other departments to help advance different projects and achieve company goals
• Represent DMPK on multidisciplinary projects and provide scientific leadership bring a fresh perspective into the team and the enthusiasm to tackle new challenges and learn new skills
• Promote and adhere to OMass’ values of being Ambitious, Responsible, Innovative, Focused, Caring and Collaborative

OMass offers an excellent benefits package including:

• Private Health Insurance
• Health and wellbeing cashback scheme
• Life Assurance and Income Protection
• Participation in Employee Equity Scheme
• 25 days annual leave, plus bank holidays
• Pension Scheme offering 6% employer contribution
• Learning and Development Opportunities
• Company social events

Any queries relating to the role can be sent to [e-mail].

OMass Therapeutics values diversity and is committed to equality of opportunity. We also have full responsibility to ensure that all employees are eligible to work and live in the UK.