Senior Director, Statistical Innovation

Ipsen Biopharmaceuticals Inc.; Greater London; Presencial; GBP 150.000 - 210.000; Jornada completa

Descripción de la vacante

Ipsen Biopharm Ltd in London is seeking a Senior Director of Statistical Innovation to lead innovative methodology, modelling, and data-driven decision support across Ipsen's R&D portfolio. You will head a 3–5 person quantitative team, guide adaptive and Bayesian trial designs, simulation, digital twins, and external controls to improve development decisions and portfolio value.

Collaborating across Clinical Development, Biostatistics, Regulatory Affairs, Data Science and asset teams, you will

Formación

• Experience leading a statistics/biometrics team.
• Strong knowledge of Bayesian and adaptive trial designs.
• Ability to communicate complex statistical results to cross-functional teams.

Responsabilidades

• Lead Statistical Innovation within Biometry and set strategy for the team.
• Provide input to innovative trial designs including adaptive, Bayesian, enrichment, external-control, master protocol.
• Develop simulation frameworks to assess operating characteristics and support go/no-go decisions.
• Lead advanced modelling across clinical development and evidence generation (disease progression, dose/regimen, patient journeys, digital twins).
• Drive data mining and predictive modelling to identify response predictors and prognostic factors.
• Advise on external controls, digital twins, Bayesian borrowing, historical data and RWE; address bias and data quality.
• Establish standards, reusable code, templates, and governance for innovation deliverables.
• Lead and develop statisticians through prioritization and coaching.
• Collaborate to ensure methods are feasible, robust, reproducible, and submission-ready.

Conocimientos

Statistical Innovation

Adaptive trial design

Bayesian methods

Data-driven decision support

Educación

PhD in Biostatistics/Statistics

Descripción del empleo

Title:

Senior Director, Statistical Innovation

Company:

Ipsen Biopharm Ltd

About Ipsen:

Ipsen is a mid‑sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation.

Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human‑centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company's success. Join us on our journey towards sustainable growth, creating real impact on patients and society!

For more information, visit us at https://www.ipsen.com/ and follow our latest news on LinkedIn and Instagram.

Job Description:

WHAT - Summary & Purpose of the Position

The Senior Director, Statistical Innovation leads innovative methodology, advanced modelling, and data-driven decision support across Ipsen's R&D portfolio, strengthening development strategy through design, simulation, and predictive analytics.

The role leads a specialist team of 3 to 5 quantitative experts supporting innovative trial design, advanced modelling, digital twins, virtual controls, patient journey modelling, and data mining to improve development decisions, study efficiency, population selection, and portfolio value.

Working closely with Clinical Development, Biostatistics, Statistical Programming, Translational Medicine, Biomarkers, Regulatory Affairs, Data Science, Business Development, Asset Teams, and Biometry Leadership, the role ensures innovative statistical approaches are scientifically rigorous, operationally feasible, and aligned with regulatory, clinical, and portfolio decision needs.

The role builds a sustainable statistical innovation capability through high‑value use cases, standards, reusable tools, external engagement, specialist talent development, and broader Biometry and asset‑team upskilling.

WHAT - Main Responsibilities & Technical Competencies

• Lead Statistical Innovation within Biometry, accountable for strategy, priorities, quality, and capability building across a 3 to 5 person specialist team.
• Provide strategic input to innovative trial designs, including adaptive, Bayesian, enrichment, external-control, master protocol, interim, simulation, and endpoint strategies.
• Develop simulation frameworks to assess operating characteristics, optimize sample size, test decision rules, and support go/no-go decisions.
• Lead advanced modelling across clinical development and evidence generation, including disease progression, dose/regimen, patient journeys, digital twins, virtual controls.
• Drive data mining and predictive modelling to identify response predictors, heterogeneity, enrichment opportunities, prognostic factors, and patient subgroups.
• Advise on external controls, digital twins, Bayesian borrowing, historical data, and RWE, addressing bias, confounding, estimands, data quality, regulatory acceptability, and interpretability.
• Identify and implement emerging statistical and modelling approaches for high‑impact Ipsen use cases.
• Establish standards, reusable code, templates, documentation, QC expectations, and governance for innovation deliverables.
• Lead and develop statisticians through prioritization, coaching, recruitment input, and succession planning.
• Work with Biostatistics and Statistical Programming to ensure methods are feasible, robust, reproducible, and submission‑ready.
• Represent Biometry in governance, asset reviews, development planning, due diligence, and external scientific discussions.
• Build external networks with academics, consortia, and industry groups to maintain methodological currency.
• Communicate complex statistical and modelling outputs clear to support peer.

HOW - Behavioural Competencies Required

Competency Competency Behavioural Markers Explanation of Choice

Ensures Accountability

• Ensures single accountable referents per task/project/outcome (independent of organizational context or multi-team projects)
• Builds and anchors an environment where people have the skills and habits to ask for clarification when accountabilities are unclear
• Consults/seeks relevant stakeholder views/expertise and coaches/ensures decisions are made by consent vs. consensus
• Takes personal accountability for decisions, actions, successes and failures, and fosters the same for others
• Follows through on commitment and makes sure others do the same
• Owns innovation strategy, methodology quality, priorities, and decision‑ready outputs.
• Develops/Coaches Talent

Able to identify and align career goals, and blend o