Head of Statistical Innovation & Advanced Modelling

Ipsen Biopharmaceuticals Inc.; Greater London; On-site; GBP 150,000 - 210,000; Full time

Job summary

Ipsen Biopharm Ltd in London is seeking a Senior Director of Statistical Innovation to lead innovative methodology, modelling, and data-driven decision support across Ipsen's R&D portfolio. You will head a 3–5 person quantitative team, guide adaptive and Bayesian trial designs, simulation, digital twins, and external controls to improve development decisions and portfolio value.

Collaborating across Clinical Development, Biostatistics, Regulatory Affairs, Data Science and asset teams, you will

Qualifications

• Experience leading a statistics/biometrics team.
• Strong knowledge of Bayesian and adaptive trial designs.
• Ability to communicate complex statistical results to cross-functional teams.

Responsibilities

• Lead Statistical Innovation within Biometry and set strategy for the team.
• Provide input to innovative trial designs including adaptive, Bayesian, enrichment, external-control, master protocol.
• Develop simulation frameworks to assess operating characteristics and support go/no-go decisions.
• Lead advanced modelling across clinical development and evidence generation (disease progression, dose/regimen, patient journeys, digital twins).
• Drive data mining and predictive modelling to identify response predictors and prognostic factors.
• Advise on external controls, digital twins, Bayesian borrowing, historical data and RWE; address bias and data quality.
• Establish standards, reusable code, templates, and governance for innovation deliverables.
• Lead and develop statisticians through prioritization and coaching.
• Collaborate to ensure methods are feasible, robust, reproducible, and submission-ready.

Skills

Statistical Innovation

Adaptive trial design

Bayesian methods

Data-driven decision support

Education

PhD in Biostatistics/Statistics

Job description

Ipsen Biopharm Ltd in London is seeking a Senior Director of Statistical Innovation to lead innovative methodology, modelling, and data-driven decision support across Ipsen's R&D portfolio. You will head a 3–5 person quantitative team, guide adaptive and Bayesian trial designs, simulation, digital twins, and external controls to improve development decisions and portfolio value.

Collaborating across Clinical Development, Biostatistics, Regulatory Affairs, Data Science and asset teams, you will