Scientist – Emerging Target Biology (Neuroscience)

Alchemab Therapeutics Ltd; Cambridge; On-site; GBP 40,000 - 80,000; Full time

Job summary

An ambitious and innovative company is seeking a Scientist to join their Emerging Target Biology Team in Cambridge. This role focuses on expanding in-house capabilities for cell-based assays and enhancing data workflows. The ideal candidate will have a strong background in cell biology, particularly with iPSC-derived neurons, and a passion for advancing therapeutic candidates in neuroscience. Join a fast-paced environment where your expertise will contribute to transformative drug discovery efforts aimed at tackling hard-to-treat diseases. This is an exciting opportunity to be part of a pioneering team dedicated to making a significant impact in the field.

Qualifications

• PhD in a relevant scientific discipline is required.
• Experience in designing complex cell and biochemical functional assays.

Responsibilities

• Design and perform cell-based functional assays independently.
• Collaborate with scientific teams and external research groups.

Skills

Cell-based functional assays

Neuroscience expertise

Data analysis and interpretation

Cell culture techniques

Experimental protocol development

Education

PhD in relevant scientific discipline

Tools

FlowJo

Graphpad Prism

Benchling

Image J

Job description

Scientist – Emerging Target Biology (Neuroscience)

Join to apply for the Scientist – Emerging Target Biology (Neuroscience) role at Alchemab Therapeutics Ltd

Scientist – Emerging Target Biology (Neuroscience)

Join to apply for the Scientist – Emerging Target Biology (Neuroscience) role at Alchemab Therapeutics Ltd

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The Scientist will be a broad ranging laboratory-based role and will help to expand our Emerging Target Biology Team. The role will bring additional cell-based functional screening, and neuroscience expertise to triage lead antibody candidates derived from Alchemab’s platform technology. Working closely within the Research team, they will build project-relevant in-house capability for a wide variety of cell-based assays. They will utilise in vitro assay development skills and demonstrate expertise with cell lines, primary cells and iPSCs to study antibody function in disease relevant assays. In addition, the successful candidate will work to improve the workflows surrounding the capture, analysis and recording of data in partnership with the Alchemab Tech team.

The role is based in Cambridge, UK.

Responsibilities

• Independently design, perform and interpret cell-based functional assays
• Assay examples may include: Cell viability and toxicity, protein aggregation, neurite outgrowth and branching analysis, mitochondrial function and oxidative stress measurements, synaptic density and function assessments, neuroinflammation, neuron activity, cell migration, BBB, phagocytosis assays, CA imaging
• Techniques may include: Western blots, ELISAs, MSD, Flow cytometry (using multi colour panels), Immunocytochemistry and Imaging, electrophysiology including multielectrode array, transcriptomic analysis including qPCR,
• Cell types may include immortalized, primary and iPSC cells in monocultures and co-culture on standard cell culture plates and in microfluidics
• Software may include: FlowJo, Graphpad Prism, Benchling, Image J
• Work with team to design, analyse and interpret results from in vivo experiments
• Work collaboratively with the Scientific team and with external research groups and partners
• Assist other areas of business as needed, including Immunology and Oncology laboratory work
• Work to improve the efficiency of data capture, analysis and recording in partnership with the Alchemab Tech team.
• Communicate efficiently, interpret and share results to different audiences.
• Maintain accurate and up-to-date electronic laboratory notebook records
• Maintain assigned laboratory equipment and/or duties
• Perform all work demonstrating due care and attention to all health and safety and COSHH regulations, and Human Tissue Act records where required
• Work closely with the scientific leadership team to review targets and help build Alchemab’s target portfolio

Experience & Requirements

• A PhD in a relevant scientific discipline (or industry equivalent)
• An ability to work independently, developing, running and trouble-shooting new scientific techniques and experimental protocols and ability to share results in clear manner
• A high attention to detail in planning and performing assays, for example pro-active inclusion of appropriate positive and negative controls
• Strong background in cell biology including prior experience performing and designing complex cell and biochemical functional assays with iPSC derived neurons
• An ambition to work with the Alchemab team to build a transformative company
• A team player who proactively and directly communicates and collaborates with other team members
• Experience in neurodegenerative disease target review
• Experience in an industrial drug discovery environment
• Experience of working in a collaborative space for example with CROs or independent academic groups
• Experience in some of the following areas: iPSC derived neurons co-culture on microfluidics, organoids, multi-electrode arrays, neurodegenerative disease mouse models

NOTE: This job description is not intended to be all inclusive. Employees may perform other related duties as negotiated to meet the ongoing needs of the organisation.

The Company

Alchemab Therapeutics is an exciting, ambitious, fast-paced antibody therapeutics company using the power of the human immune system to discover the next targets and therapies for hard-to-treat diseases. The company brings together cutting-edge technologies, including antibody repertoire profiling, deep learning and proteomics and world-leading expert founders and management team. Alchemab is initially focused on the areas of neuroscience and oncology.

Founded in 2019, Alchemab aims to deliver a pipeline of targets and therapeutic candidates moving into clinical development in 2025 and beyond. We share the bold ambition to be a transformational therapeutics company with a broad pipeline of internal and partnered novel targets & candidates.

Note to recruitment agencies: we are not looking for assistance at this stage so please contact the HR department only at [e-mail] if you think you can help in the future.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science and Research

• Industries

  Biotechnology Research and Pharmaceutical Manufacturing

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