Scientist – Emerging Target Biology (Immunology)

ONE NUCLEUS; Cambridge; On-site; GBP 35,000 - 65,000; Full time

Job summary

An established industry player is seeking a Scientist to join their Emerging Target Biology Team in Cambridge. This laboratory-based role involves leveraging cell-based functional screening and immunology expertise to enhance workflows and develop in-house capabilities for various assays. The successful candidate will work on innovative projects, collaborating closely with the Research team and external partners to drive advancements in antibody candidate triage. If you are passionate about scientific innovation and eager to contribute to a transformative company, this role offers a unique opportunity to make a significant impact in the field.

Qualifications

• PhD in a relevant scientific discipline or industry equivalent required.
• Strong background in cell biology and immunology essential.
• Experience in drug discovery and collaboration with CROs preferred.

Responsibilities

• Design and perform cell-based functional assays independently.
• Utilize various techniques including flow cytometry and immunocytochemistry.
• Collaborate with scientific teams and improve data workflows.

Skills

Cell-based functional assays

Immunology expertise

Flow cytometry

Data analysis

Cell culture

Assay development

Communication skills

Troubleshooting

Education

PhD in a relevant scientific discipline

Tools

FlowJo

GraphPad Prism

Benchling

ImageJ

Job description

The Scientist will be a broad-ranging laboratory-based role aimed at expanding our Emerging Target Biology Team. The role involves bringing cell-based functional screening and immunology expertise to triage lead antibody candidates derived from Alchemab’s platform technology. Working closely within the Research team, the scientist will develop in-house capabilities for various cell-based assays, utilizing in vitro assay development skills and demonstrating expertise with cell lines and primary cells to study antibody functions in disease-relevant assays. Additionally, the candidate will work to improve workflows for data capture, analysis, and recording in partnership with the Alchemab Tech team.

The role is based in Cambridge, UK.

Responsibilities

1. Independently design, perform, and interpret cell-based functional assays, including viability, proliferation, apoptosis, migration, invasion, T-cell activation, MLR, ADCC, and CDC.
2. Utilize techniques such as cell culture, Western blots, ELISAs, MSD, flow cytometry, immunocytochemistry, imaging, and transcriptomic analysis including qPCR.
3. Work with various cell types, including immortalized and primary cells from human blood samples, in monocultures and 3D formats.
4. Use software tools like FlowJo, GraphPad Prism, Benchling, and ImageJ.
5. Design, analyze, and interpret results from in vivo experiments.
6. Assist other business areas, including Neuroscience and Oncology laboratories.
7. Collaborate with the Scientific team and external research groups.
8. Improve data capture, analysis, and recording workflows with the Tech team.
9. Communicate results effectively to different audiences.
10. Maintain accurate electronic laboratory notebooks and equipment.
11. Adhere to health, safety, COSHH, and Human Tissue Act regulations.
12. Work with scientific leadership to review targets and build Alchemab’s target portfolio.

Experience & Requirements

Essential:

• PhD in a relevant scientific discipline or industry equivalent.
• Ability to work independently, troubleshoot, and communicate results clearly.
• High attention to detail in assay planning and execution.
• Strong background in cell biology, including designing complex cell and biochemical assays with immunological readouts, and expertise in flow cytometry.
• Ambition to contribute to building a transformative company.
• Proactive team player with good communication skills.
• Experience in immunology target review.
• Experience in an industrial drug discovery environment.
• Experience collaborating with CROs or academic groups.

Note: This job description is not all-inclusive. Employees may perform other duties as needed.

Application Instructions:

If interested, please apply via the provided link.