Scientist - Emerging Target Biology (Immunology)

Alchemab Therapeutics Ltd; Cambridge; On-site; GBP 40,000 - 80,000; Full time

Job summary

An exciting opportunity awaits you at a forward-thinking biotechnology firm, where you'll play a pivotal role as a Scientist in Emerging Target Biology. This dynamic position involves utilizing your expertise in immunology and cell-based assays to advance innovative therapeutic candidates. Join a passionate team dedicated to transforming the landscape of antibody therapeutics and making a meaningful impact on hard-to-treat diseases. With a focus on collaboration and cutting-edge technology, this role offers a chance to be at the forefront of scientific discovery and contribute to a transformative pipeline of novel therapies. If you are driven by ambition and a desire to collaborate, this is the perfect opportunity for you.

Qualifications

• Strong background in cell biology and immunological assays.
• Experience in designing and performing complex functional assays.
• Ability to work independently and share results clearly.

Responsibilities

• Design and perform cell-based functional assays independently.
• Collaborate with teams to analyze and interpret results.
• Maintain accurate electronic laboratory notebook records.

Skills

Cell-based functional assays

Immunology expertise

Flow cytometry

Cell culture

Data analysis

Experimental protocol development

Education

PhD in a relevant scientific discipline

Tools

FlowJo

Graphpad Prism

Benchling

Image J

Job description

Scientist - Emerging Target Biology (Immunology)

Join to apply for the Scientist - Emerging Target Biology (Immunology) role at Alchemab Therapeutics Ltd

Scientist - Emerging Target Biology (Immunology)

Join to apply for the Scientist - Emerging Target Biology (Immunology) role at Alchemab Therapeutics Ltd

The Scientist will be a broad ranging laboratory-based role and will help to expand our Emerging Target Biology Team. The role will bring additional cell-based functional screening, and immunology expertise to triage lead antibody candidates derived from Alchemab’s platform technology. Working closely within the Research team, they will build project-relevant in-house capability for a wide variety of cell-based assays. They will utilise in vitro assay development skills and demonstrate expertise with cell lines, and primary cells to study antibody function in disease relevant assays. In addition, the successful candidate will work to improve the workflows surrounding the capture, analysis and recording of data in partnership with the Alchemab Tech team.

The role is based in Cambridge, UK.

Responsibilities

• Independently design, perform and interpret cell-based functional assays
• Assay examples may include: Cell viability and proliferation, Apoptosis, transwell migration and invasion assay, T-cell Activation and Proliferation (including antigen recall), Mixed Lymphocyte Reaction (MLR), Antibody-Dependent Cellular Cytotoxicity (ADCC), Complement-Dependent Cytotoxicity (CDC),
• Techniques may include: Cell culture, Western blots, ELISAs, MSD, Flow cytometry (using multi colour panels), Immunocytochemistry and Imaging, transcriptomic analysis including qPCR,
• Cell types may include immortalized and primary cells (including cells derived from human blood samples) in monocultures and 3D formats
• Software may include: FlowJo, Graphpad Prism, Benchling, Image J
• Work with team to design, analyse and interpret results from in vivo experiments
• Assist other areas of business as needed, including Neuroscience and Oncology laboratory work
• Work collaboratively with the Scientific team and with external research groups and partners
• Work to improve the efficiency of data capture, analysis and recording in partnership with the Alchemab Tech team.
• Communicate efficiently, interpret and share results to different audiences.
• Maintain accurate and up-to-date electronic laboratory notebook records
• Maintain assigned laboratory equipment and/or duties
• Perform all work demonstrating due care and attention to all health and safety and COSHH regulations, and Human Tissue Act records where required
• Work closely with the scientific leadership team to review targets and help build Alchemab’s target portfolio

Experience & Requirements

• A PhD in a relevant scientific discipline (or industry equivalent)
• An ability to work independently, developing, running and trouble-shooting new scientific techniques and experimental protocols and ability to share results in clear manner
• A high attention to detail in planning and performing assays, for example pro-active inclusion of appropriate positive and negative controls
• Strong background in cell biology including prior experience performing and designing complex cell and biochemical functional assays with immunological readouts on primary cells including primary PBMCs and/or T cells, and expertise in flow cytometry
• An ambition to work with the Alchemab team to build a transformative company
• A team player who proactively and directly communicates and collaborates with other team members
• Experience in Immunology target review
• Experience in an industrial drug discovery environment
• Experience of working in a collaborative space for example with CROs or independent academic groups
• Experience in some of the following areas: T-cell Activation and Proliferation (including antigen recall), Mixed Lymphocyte Reaction (MLR), transwell migration and invasion assay

NOTE: This job description is not intended to be all inclusive. Employees may perform other related duties as negotiated to meet the ongoing needs of the organisation.

The Company

Alchemab Therapeutics is an exciting, ambitious, fast-paced antibody therapeutics company using the power of the human immune system to discover the next targets and therapies for hard-to-treat diseases. The company brings together cutting-edge technologies, including antibody repertoire profiling, deep learning and proteomics and world-leading expert founders and management team. Alchemab is initially focused on the areas of neuroscience and oncology.

Founded in 2019, Alchemab aims to deliver a pipeline of targets and therapeutic candidates moving into clinical development in 2025 and beyond. We share the bold ambition to be a transformational therapeutics company with a broad pipeline of internal and partnered novel targets & candidates.

Note to recruitment agencies: we are not looking for assistance at this stage so please contact the HR department only at [e-mail] if you think you can help in the future.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science and Research

• Industries

  Biotechnology Research and Pharmaceutical Manufacturing

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