Scientific Manager, High Throughput Laboratory

Flagship Pioneering; Cambridge; On-site; GBP 55,000 - 75,000; Full time

Job summary

A leading biotechnology company in Cambridge is seeking a Scientific Manager to support its High Throughput Laboratory. The role involves managing a small team, executing laboratory workflows related to cell and tissue processing, and ensuring compliance with regulatory standards. Candidates should have a Bachelor’s degree and at least 6 years of relevant experience, especially in histology and flow cytometry. The company fosters innovative solutions in healthcare and values diverse teams.

Qualifications

• Minimum 6 years of experience in relevant field.
• Experience working in high throughput/pipeline platform.
• Ability to work in a matrix environment.

Responsibilities

• Lead a small team in executing laboratory workflows.
• Interact with cross-functional teams for project requirements.
• Manage compliance with regulatory requirements.

Skills

Histology

Flow cytometry

Molecular Biology

Sample management

Communication skills

Team management

Attention to detail

Education

Bachelor’s degree in relevant field

Tools

Electronic Lab Notebook (ELN)

Job description

Company Summary

Quotient Therapeutics, Inc. is a privately held, early‑stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first‑in‑category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Seres Therapeutics (NASDAQ: MCRB), Sana Biotechnology (SANA), Axcella Health (AXLA), Indigo Agriculture, Generate Biomedicines, and Tessera Therapeutics.

Position Summary

We are seeking a scientific manager to support Quotient’s High Throughput Laboratory. This is a cross‑functional management role requiring an understanding of laboratory workflows used to isolate and sequence human cells for the evaluation of somatic genomic variants. The successful candidate will lead a small team of lab‑based scientists in the prioritization and execution of cell/tissue based and molecular workflows, and act as a liaison between the High Throughput Laboratory and the Target Discovery team.

An ideal candidate will be familiar with at least two of the following: histology, flow cytometry and molecular workflows. A proactive attitude towards learning and bridging skills gaps from the above skills panel is essential.

Key Responsibilities

• Attend project meetings; interact with cross‑functional teams to understand broad project requirements and subsequently implement streamlined workflows through the High Throughput Laboratory to deliver on project objectives.
• Active member of the High Throughput lab team supporting the team where needed to deliver on bench‑based processes. This will include all/any of the following:
  • Histology (tissuefixation, embedding, sectioning, histochemistry (IHC, H&E))
  • Flow cytometry (FACS/FANS, tissue dissociation, cell/nuclei counting, immunostaining)
  • Molecular (DNA/RNA handling, Library generation, sequencing submissions).
• Management of Research Associates with scope to grow the team.
• Manage sample workflows to ensure visibility of sample status throughout the project lifecycle.
• Maintain team compliance with regulatory requirements and quality standards, including the Human Tissue Act and COSHH.

Key Skills and Experience

• Bachelor’s degree plus minimum 6 years of experience in relevant field. MSc and PhD considered against hands on experience. Candidates with scientific management experience will be prioritized.
• Hands on expertise in histology, flow cytometry and/or molecular Biology.
• Experience working in a high throughput/pipeline platform.
• Familiarity with using ELN for recording laboratory processing as well as sample status.
• Broad understanding of tissue/cell biology and molecular genetics.
• Ability to work both quickly and diligently, completing high‑quality work on schedule.
• Excellent verbal and written communication skills.
• Ability to work successfully in a matrix environment, where tasks may be assigned by people other than your direct line manager.
• Ability to prioritize and manage multiple tasks simultaneously, and balance competing priorities effectively.
• A high degree of energy, accuracy and attention to detail, and a passion for contributing to work leading to the creation of transformative medicines for patients with serious diseases.
• HTA awareness is advantageous.
• Experience of spatial transcriptomics would be advantageous.

Location

Cambridge, UK

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID‑19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies

Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.