Protein Scientist / Senior Scientist

Sygnature Discovery Limited; Macclesfield; On-site; GBP 42,000 - 62,000; Full time

Benefits offered by this job

25 days annual leave (plus bank public

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Enhanced Family Friendly Policies

Sygnature Group Pension Scheme

1 paid volunteer day per year

Job summary

Sygnature Discovery Limited in Macclesfield invites applications for Scientists and Senior Scientists to join our Protein Science team on a 6-month contract at Tytherington. We seek curious, hands-on scientists with experience in protein expression, purification and structural determination.

You will work across bacterial, insect and mammalian expression, purification, and structural biology techniques including X-ray crystallography, NMR and Cryo-EM, collaborating with colleagues on a diverse

Qualifications

• BSc/MSc or PhD in Biochemistry or a related discipline.
• Experience in protein expression, purification and structural determination.
• Experience in protein engineering and biophysical/structural characterization techniques is advantageous.
• Good communication and teamwork skills are essential.
• Excellent problem-solving skills in protein expression, purification and structural biology.
• Strong interpersonal and communication skills; broad scientific curiosity.

Responsibilities

• Protein Expression involving recombinant proteins in bacterial, insect and mammalian systems.
• Protein purification and analysis of a broad range of targets including membrane proteins.
• Structural Biology – X-ray crystallography, biomolecular NMR and CryoEM.

Skills

Protein expression

Protein purification

Structural biology

Teamwork

Communication

Problem solving

Education

BSc/MSc/PhD in Biochemistry or related

Tools

X-ray crystallography

Cryo-EM

NMR

Job description

About Sygnature Discovery

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 250 patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.

About the role

Our Protein Science team specialises in the engineering, expression and purification of tailored proteins across a wide range of protein classes for applications including biochemical screening, biophysics, diagnostics and biologics drug discovery. We also have a dedicated team of scientists carrying out structural studies using X-ray crystallography, Cryo-EM and protein NMR, giving you the opportunity to work alongside experts across multiple disciplines using cutting‑edge technologies.

Due to continued growth, we're looking for Scientists and Senior Scientists to join our Protein Science team at our Tytherington site in Macclesfield on a 6- month contract. We're looking for curious and passionate scientists with hands‑on experience in either protein expression, purification and structural determination. Experience in protein engineering and biophysical or structural characterisation techniques would be an advantage.

As a global CRO, you'll have the opportunity to work across a diverse portfolio of client projects rather than focusing on a single programme. You'll collaborate with talented scientists from across the business, tackle a broad range of scientific challenges and help our clients accelerate the discovery of tomorrow's medicines.

If you're looking for variety, enjoy solving complex scientific problems and want to be part of a collaborative, innovative team, we'd love to hear from you.

Role Responsibilities

• Protein Expression involving the expression of recombinant proteins in bacterial, insect and mammalian systems
• Protein purification and analysis of a broad range of targets including membrane proteins
• Structural Biology – X-ray crystallography, biomolecular NMR and CryoEM

Skills & Qualifications

• As a minimum you will have a BSc/MSc or PhD in Biochemistry or a related discipline
• Drugs discovery experience in a CRO is advantageous however not essential
• Successful project delivery will be achieved through your own individual experimental work and by working flexibly with colleagues.G
• ood communication and team working skills are therefore essential
• Excellent problem‑solving skills and in some of the techniques involved in protein expression, purification and analysis including structural biology.
• Strong interpersonal and communications skills and a natural broader curiosity

Benefits

• 25 days annual leave (plus bank holidays)
• Private Medical Insurance
• Life Insurance
• Employee Assistance Programme
• Enhanced Family Friendly Policies
• Sygnature Group Pension Scheme
• 1 paid volunteer day per year

Please note: This advert may close early if we receive a high volume of applications. We encourage you to submit your application as soon as possible to avoid missing out on this opportunity.