Associate Principal Scientist/Principal Scientist - Medicinal Chemistry

Sygnature Discovery Limited; Monks Heath; On-site; GBP 70,000 - 100,000; Full time

Benefits offered by this job

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Pension Scheme

Job summary

Sygnature Discovery Limited is seeking an experienced Associate Principal Scientist / Principal Scientist for our Chemistry team at Alderley Park. You will lead medicinal chemistry programmes, shape project strategies, and mentor scientists across cross-disciplinary teams.

You will collaborate with Bioscience, DMPK, and other disciplines to define integrated project strategies, influence scientific direction, and communicate progress to clients and internal teams.

Qualifications

• Proven track record of leading multidisciplinary drug discovery projects.
• Broad understanding of integrated drug discovery across disciplines.
• Strong people leadership with mentoring and coaching experience.
• Excellent communication and stakeholder management to influence diverse audiences.
• Commercial awareness with client interaction and proposals.
• Motivated and adaptable in a fast-paced, collaborative environment.

Responsibilities

• Lead and influence complex medicinal chemistry programmes across pre-clinical stages.
• Develop high performing project teams and ensure delivery of excellent science.
• Communicate scientific strategy and project outcomes to internal and external stakeholders.
• Contribute to operational strategy, business growth, recruitment, and capability development.
• Mentor, coach, train, and manage performance of scientists across the department.
• Uphold high standards of laboratory practice, data integrity, safety, and compliance.
• Represent Sygnature externally through client engagement, publications, and conferences.

Skills

Leadership

Communication

Stakeholder management

Commercial awareness

Adaptability

Multidisciplinary collaboration

Education

PhD in Organic/Medicinal Chemistry or related

Job description

About Sygnature Discovery

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 250 patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.

About the role:

Our Chemistry team at Alderley Park is looking for an experienced Associate Principal Scientist / Principal Scientist to join the team.

We’re looking for someone with significant experience leading medicinal chemistry programmes within a pharmaceutical, biotechnology or CRO environment. This is a senior and influential role where you’ll help shape project strategy, develop high-performing scientists through effective mentoring and coaching, and contribute to the continued growth and success of the site.

You’ll work closely with colleagues across Bioscience and DMPK and other scientific disciplines to define and execute integrated project strategies. Strong experience of working within multidisciplinary drug discovery teams, influencing scientific direction and communicating effectively with both internal teams and clients, will therefore be essential.

This is a fantastic opportunity to work across diverse drug discovery projects for a range of clients, offering genuine breadth and depth of scientific experience. If this sounds like the next challenge you’d like to embark on - we’d love to hear from you.

Role Responsibilities:

• Lead and influence complex medicinal chemistry programmes, at any stage of pre-clinical development


• Develop high performing project teams, ensuring the delivery of excellent science and successful project outcomes.


• Communicate scientific strategy and key project outcomes, whilst simultaneously manage all stakeholders, both internal and external


• Provide leadership beyond project delivery by contributing to operational strategy, business growth, recruitment, capability development, and continuous improvement programmes across the department.


• Contribute to the development of high-performing scientists through effective mentoring, coaching, training, and performance management.


• Maintain the highest standards of laboratory practice, data integrity, health & safety, and professionalism, ensuring teams are appropriately trained, fully compliant with all relevant company policies, and consistently maintain a safe and productive working environment.


• Represent Sygnature externally through client engagement, scientific presentations, publications, conference participation, and professional networking activities.

Skills & Qualifications:

• PhD in Organic Chemistry, Medicinal Chemistry, or a related discipline, or equivalent industrial experience.


• Proven track record of leading multidisciplinary drug discovery projects and delivering scientific success.


• Broad understanding of integrated drug discovery and the ability to work effectively across multiple scientific disciplines.


• Strong people leadership skills, with experience mentoring, coaching, and developing scientists at different career stages.


• Excellent communication and stakeholder management skills, with the ability to influence both scientific and non-scientific audiences.


• Commercial awareness and experience working with clients, supporting proposals, and contributing to business growth.


• Motivated, adaptable, and comfortable operating in a fast-paced and collaborative environment.

Benefits

• 25 days annual leave (plus bank holidays)


• Private Medical Insurance


• Life Insurance


• Employee Assistance Programme


• Enhanced Family Friendly Policies


• Sygnature Group Pension Scheme


• 1 paid volunteer day per year

Please note: This advert may close early if we receive a high volume of applications. We encourage you to submit your application as soon as possible to avoid missing out on this opportunity.