Principal Translational PK/PD Modeller

RBW Consulting

Greater London

On-site

GBP 90,000 - 130,000

Full time

8 days ago

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Job summary

RBW Consulting is seeking an experienced Principal Scientist to drive quantitative pharmacology strategies across drug discovery and development, influencing project strategy from early research to clinical development.

The role focuses on translational modelling, mechanistic PK/PD modelling, and collaboration across translational medicine, safety sciences, and clinical development to inform key development decisions.

Qualifications

PhD in Systems Biology, Pharmacometrics, PK/PD, or a related discipline.
Strong experience applying modelling and simulation approaches within drug discovery and development.
Demonstrated ability to design and execute quantitative pharmacology strategies spanning research through early clinical development.
Experience working within complex, matrixed R&D environments.
Proficiency with modelling tools such as R, Monolix, Phoenix, or similar platforms.
Excellent communication skills, with the ability to influence stakeholders across scientific disciplines.

Responsibilities

Lead quantitative pharmacology and translational modelling strategies across a diverse project portfolio.
Integrate preclinical and translational data to inform decision-making and support progression into clinical development.
Develop mechanistic and PK/PD models to evaluate hypotheses, optimise study design, and support strategic development plans.
Collaborate with multidisciplinary teams across areas such as translational medicine, safety sciences, bioanalysis, and clinical development.
Provide scientific leadership on modelling and simulation activities both internally and through external partnerships.
Contribute to regulatory documentation and strategic submissions where required.