Postdoctoral Neuroscientist

University of Oxford; Oxford; On-site; GBP 39,000 - 48,000; Full time

Job summary

The University of Oxford's Nuffield Department of Clinical Neurosciences invites applications for a Postdoctoral Neuroscientist at John Radcliffe Hospital in Oxford. The role focuses on developing human cellular models of peripheral neuropathy using iPSC-derived sensory neurons and advanced culture techniques.

You will investigate neural injury responses, Wallerian degeneration pathways and genome-wide CRISPR screens to map molecular regulators of cell death and axonal destruction.

Qualifications

• Interest in neural injury and iPSC models
• Experience with cellular biology techniques
• Familiarity with CRISPR screens and data analysis

Responsibilities

• Develop human cellular models of peripheral neuropathy using iPSC-derived sensory neurons
• Apply advanced culture techniques and cellular stressors to model neuropathies
• Investigate downstream molecular pathways mediating cell death and axonal destruction with targeted and genome-wide approaches

Job description

Postdoctoral Neuroscientist

Nuffield Department of Clinical Neurosciences (NDCN) - John Radcliffe Hospital, Headington, Oxford, OX3 9DU

This post is an exciting opportunity provided by funding from the Adelson Medical Research Foundation. The aim of this post is to develop human cellular models of peripheral neuropathy to test novel therapeutic avenues. These will include rare inherited neuropathies and diabetic peripheral neuropathy using sensory neurons differentiated from induced pluripotent stem cells and to model them using advanced culture techniques (such as microfluidic chambers) and cellular stressors (which may be metabolic, drug induced including activators of SARM a key component of the Wallerian degeneration pathway or traumatic neuropathies). We will investigate the downstream molecular pathways mediating cell death and axonal destruction using both targeted approaches but also genome-wide CRISPR screen. The post will therefore suit an applicant who has an interest in the response to neural injury, the Wallerian degeneration pathways, iPSC models and some expertise in molecular biology.

For any queries regarding visa sponsorship, HR and the University's Staff Immigration Team will provide advice and assistance when the chosen candidate for the role has been identified.

The post is full time for a fixed term until 30th of September 2028.

Interviews will be held as soon as possible thereafter.

Contact Person: NDCN HR Recruitment

Vacancy ID: 189476

Contact Phone:

Closing Date & Time: 02-Nov-2026 12:00

Pay Scale: RESEARCH GRADE 7

Contact Email: [e-mail]

Salary (£): Research Grade 7: £39,424 - £47,779 per annum A less experienced candidate may be appointed at Grade 6 (£35,681- £41,636 per annum), with a commensurate adjustment in either the essential criteria, responsibilities or duties.

Tagged as: Life Sciences