PhD: Precision NF1 Variant Editing & Zebrafish

University of Exeter; Exeter; On-site; GBP 20,000 - 24,000; Full time

Job summary

University of Exeter offers a PhD studentship addressing the NF1 genotype–phenotype gap using data science and functional genomics. The project combines in vitro and in vivo analyses, including zebrafish models, CRISPR/Cas9 genome editing, and AI-based approaches to map variants to signalling pathways and organismal phenotypes.

The student will establish a humanised zebrafish platform, apply precise genome editing such as prime editing, and study tissue patterning and drug responses using

Qualifications

• Background in biology/genetics with strong data science skills.
• Experience with zebrafish models and genome editing techniques.
• Ability to integrate data science with functional genomics.

Responsibilities

• Identify and prioritise human NF1 variants across datasets.
• Assess effects on NF1-dependent signalling in cellular systems.
• Validate genetic variants in zebrafish models and develop humanised platforms.
• Perform genome editing using CRISPR/Cas9 and prime editing techniques.
• Quantify cellular phenotypes and analyse pharmacological responses.

Skills

Data science

In vitro analysis

In vivo analysis

CRISPR/Cas9

Zebrafish model

AI-based approaches

Genetics

Tools

CRISPR/Cas9

Prime editing

Imaging techniques

Job description

University of Exeter offers a PhD studentship addressing the NF1 genotype–phenotype gap using data science and functional genomics. The project combines in vitro and in vivo analyses, including zebrafish models, CRISPR/Cas9 genome editing, and AI-based approaches to map variants to signalling pathways and organismal phenotypes.

The student will establish a humanised zebrafish platform, apply precise genome editing such as prime editing, and study tissue patterning and drug responses using