PhD: CRISPR Epigenome Editing in Alzheimer’s

University of Exeter; Exeter; Presencial; GBP 18.000 - 24.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Home tuition fees covered

Doctoral stipend up to 4 years

Descripción de la vacante

University of Exeter is offering a PhD studentship focused on Alzheimer's disease-related epigenomics. The project integrates cell-type-specific DNA methylation, ATAC-seq and H3K27ac data to identify regulatory loci within brain cells and prioritize candidates for functional validation.

Selected loci will be functionally interrogated using targeted CRISPR epigenome editing in hiPSC-derived neural cells (cortical neurons/microglia), with downstream analyses of gene expression and cellular

Descripción del empleo

University of Exeter is offering a PhD studentship focused on Alzheimer's disease-related epigenomics. The project integrates cell-type-specific DNA methylation, ATAC-seq and H3K27ac data to identify regulatory loci within brain cells and prioritize candidates for functional validation.

Selected loci will be functionally interrogated using targeted CRISPR epigenome editing in hiPSC-derived neural cells (cortical neurons/microglia), with downstream analyses of gene expression and cellular