Postdoctoral Research Associate, Cardiocvascular Research

1000scholars; Greater London; On-site; GBP 37,000 - 50,000; Full time

Job summary

St George's University of London in London invites applications for a Postdoctoral Research Associate in Cardiocascular Research to advance genetic models of Brugada syndrome.

You will design CRISPR-mediated knockdowns in zebrafish, assess effects on heart function, and optimize protocols while contributing to data analysis and dissemination in a multidisciplinary team.

Qualifications

• PhD in molecular biology, cellular biology, biochemistry or a related discipline.
• Experience with gene editing methodologies.
• Experience with zebrafish husbandry and disease models.
• Experience designing and executing functional assays.

Responsibilities

• Design CRISPR-mediated gene knockdown of zebrafish orthologues for Brugada genes and assess effects on heart function.
• Implement new techniques and optimize protocols critical to the project and provide troubleshooting input.
• Work with limited supervision and contribute to data analysis and interpretation.

Skills

Gene editing methodologies

Zebrafish husbandry

Functional assays design

Data analysis

CRISPR

Education

PhD in molecular biology or related discipline

Tools

CRISPR gene editing

Job description

Postdoctoral Research Associate, Cardiocvascular Research

St George's University of London

London, United Kingdom

GBP 43,482 per year

Responsibilities

The main responsibilities of this role will be to design CRISPR-mediated gene knockdown of zebrafish orthologues for novel putative Brugada genes and undertake functional analyses to assess the effect of these knockdowns on heart function. You will also be expected to implement new techniques and optimize protocols critical to the project and provide technical expertise and input for troubleshooting of experiments. It is expected that you will work with limited supervision and contribute to data analysis and interpretation.

Person Specification

We are looking for a person with a PhD in molecular biology, cellular biology, biochemistry or a related discipline. You should have practical expertise with gene editing methodologies and extensive direct experience of zebrafish husbandry techniques and the development of zebrafish disease models. You should also have experience in designing and executing functional assays for evaluating the effects of gene mutations, as well as excellent technical and problem-solving skills, and the ability to work effectively in a multi-disciplinary team.

Deadline 25 October