PhD in Rare Variant Genomics to Decode Musculoskeletal Disease

University of Exeter; Exeter; Vor Ort; GBP 18.000 - 21.000; Vollzeit

Benefits dieser Stelle

Doctoral stipend

Zusammenfassung

University of Exeter in collaboration with the University of Oxford invites applications for a funded PhD studentship focused on rare genetic variants driving musculoskeletal disorders. The project combines health data science, statistical genomics, and molecular genetics to uncover causal genes and mechanisms.

Phase 1 is computational analysis using large datasets; Phase 2 moves to laboratory validation in tissue models, CRISPR editing, and functional genomics to define disease pathways and

Aufgaben

• Analyze millions of individuals with whole genome sequencing and medical records to identify rare variants causing musculoskeletal disorders.
• Functionally characterise prioritised variants in disease-relevant primary human cell and tissue models.
• Investigate molecular pathways connecting genotype to disease and identify potential therapeutic targets.

Jobbeschreibung

University of Exeter in collaboration with the University of Oxford invites applications for a funded PhD studentship focused on rare genetic variants driving musculoskeletal disorders. The project combines health data science, statistical genomics, and molecular genetics to uncover causal genes and mechanisms.

Phase 1 is computational analysis using large datasets; Phase 2 moves to laboratory validation in tissue models, CRISPR editing, and functional genomics to define disease pathways and