Funded PhD: Allele-Resolved Epigenetics in Type 2 Diabetes

University of Exeter; Exeter; On-site; GBP 21,000 - 23,000; Full time

Benefits offered by this job

Stipend

Fees covered

EPSRC funded

Job summary

University of Exeter invites applications for a PhD studentship focusing on how genetic variants affect DNA regulation in pancreatic islets. The project uses Fiber-seq long-read sequencing to map regulatory activity and distinguish parental copies, advancing diabetes genetics.

You will join a multidisciplinary team with training in experimental design, sequencing, bioinformatics, and statistical genetics, receiving expert supervision and international collaboration opportunities.

Qualifications

• Experience in genetics/genomics research and data analysis.
• Strong computational and statistical skills with a biology background.
• Ability to work with large-scale sequencing data and collaborate.

Responsibilities

• Generate chromatin maps from healthy and diabetic islets using Fiber-seq.
• Analyze regulatory activity, epigenetic state, and genotype across parental copies.
• Integrate data with UK Biobank and other large cohorts for interpretation.
• Collaborate across lab and software teams with international partners.

Skills

Bioinformatics

Epigenetics

Chromatin sequencing

Education

Bachelor's degree in a related field

Tools

Oxford Nanopore

R/Python

Job description

University of Exeter invites applications for a PhD studentship focusing on how genetic variants affect DNA regulation in pancreatic islets. The project uses Fiber-seq long-read sequencing to map regulatory activity and distinguish parental copies, advancing diabetes genetics.

You will join a multidisciplinary team with training in experimental design, sequencing, bioinformatics, and statistical genetics, receiving expert supervision and international collaboration opportunities.