Lead LC-MS Method Development & Validation

Nexus Life Sciences; Reading; On-site; GBP 36,000 - 60,000; Full time

Job summary

Nexus Life Sciences in Reading, United Kingdom, is seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards and to lead the Method Development & Validation team.

You will optimise extraction techniques and chromatography, transfer validated methods, support regulatory submissions, and mentor staff in a cutting-edge lab environment.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• GxP laboratory experience with GLP
• Experience with method development, optimisation and validation
• Strong problem-solving and troubleshooting capabilities
• Knowledge of protein precipitation, SPE, and liquid-liquid extraction techniques
• Understanding of regulatory and GLP requirements

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise extraction techniques, chromatography methods, and LC columns.
• Mentor and manage the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and implement improvements.
• Oversee cost-effective laboratory operations and consumables.
• Write and approve Methods of Analysis and transfer validated methods to teams.
• Support regulatory submissions and respond to queries.
• Lead CAPA investigations and drive continuous improvement.
• Lead team meetings and staff development sessions.

Skills

HPLC/UPLC/LCMSMS

Method development

Validation

GxP/GLP compliance

Leadership

Communication

Problem solving

Education

Biochemistry related degree

Tools

Empower

Mass Lynx

Design of Experiments (DOE)

Job description

Nexus Life Sciences in Reading, United Kingdom, is seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards and to lead the Method Development & Validation team.

You will optimise extraction techniques and chromatography, transfer validated methods, support regulatory submissions, and mentor staff in a cutting-edge lab environment.