In Vivo Scientist

ZipRecruiter; Cambridge; On-site; GBP 35,000 - 65,000; Full time

Job summary

An innovative firm is seeking a dedicated candidate to manage mouse colonies and perform in vivo experiments. This role involves hands-on work with hematopoietic stem cells, including intravenous injections and blood collection. The successful candidate will collaborate with a dynamic team to support process development and optimization of cell therapies. With a focus on advanced techniques and statistical analysis, this position offers a unique opportunity to contribute to groundbreaking research in cell biology. Join a forward-thinking organization that values collaboration and scientific excellence.

Qualifications

• Advanced degree in molecular biology or pharmacology required.
• Experience with human iPSC and HSC is essential.

Responsibilities

• Design and conduct in vivo studies for hematopoietic stem cell engraftment.
• Collaborate with teams to resolve issues and lead projects.

Skills

In vivo techniques

Animal handling

Flow cytometry

Statistical analysis

Problem-solving

Education

M.S. or Ph.D. in Molecular Biology

Industry experience (2+ years)

Tools

FlowJo

Rotea counterflow centrifuge

PBS vertical wheel

Job description

Job Description:

The successful candidate will have outstanding expertise in mouse handling and mouse procedures. They will be responsible for managing mouse colonies, performing project-specific in vivo experiments, intravenous injections of hematopoietic stem cells in humanized murine models, retro-orbital and submandibular blood collection, and blood cell FACS analyses and in vivo imaging. This is a collaborative role partnering with other team members to assist with project-specific in vivo experiments and other needs across the process development function.

Role and Responsibilities:

1. Hands-on role with a commitment to designing, conducting, and analyzing in vivo studies to assess engraftment of hematopoietic stem cells.
2. Execute pluripotent stem cell culture and differentiation into hematopoietic stem cells to support process development, optimization, and characterization.
3. Document experimental procedures and results according to established guidelines; perform statistical analysis of experimental data.
4. Collaborate effectively within departmental teams, engage in team discussions to resolve issues, and lead projects with a fully integrated team to facilitate successful outcomes.
5. Prior experience in bioreactor-based process development for iPSC-derived cell therapies is highly desirable.

Qualifications:

• Advanced degree (M.S. or Ph.D.) in molecular biology or pharmacology, with at least 2 years of industry experience.
• Experience working with human induced pluripotent stem cells (iPSC), hematopoietic stem cells (HSC), and/or immune cell biology; including scale-up processes utilizing bioreactors such as PBS vertical wheel, Rotea counterflow centrifuge.
• Proficiency with in vivo techniques including animal handling, intra-bone and intravenous transplants, blood collection, and tissue dissection.
• Experience in standard processing techniques including flow cytometry, molecular biology assays such as CFUs, immunological assays, and aseptic cell culture techniques.
• Experience with experiment design tools such as FlowJo and practical knowledge of statistical analysis.
• Strong organizational, analytical, problem-solving, root-cause analysis, and troubleshooting skills.

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