Hybrid DMPK Lead - AI-Driven Drug Discovery

Isomorphic Labs; England; Hybrid; GBP 110,000 - 150,000; Full time

Benefits offered by this job

Hybrid working 3 days in office

Commitment to equal opportunities

Job summary

Isomorphic Labs is seeking a DMPK Lead to drive the DMPK strategy across drug discovery projects, coordinating with cross-functional teams to deliver high-quality clinical candidates. You will integrate pharmacokinetics, translational research, and regulatory considerations, leveraging AI-enabled models and state-of-the-art data integrations to inform decision making.

The role requires extensive experience in DMPK across multiple modalities, collaboration with preclinical and clinical teams, and

Qualifications

• PhD in Pharmaceutical Science, Pharmacy, Chemistry or related field.
• 8+ years of professional DMPK lead experience with a track record of delivering high-quality candidates.
• Experience supporting DMPK across multiple modalities and collaboration with preclinical/clinical teams.

Responsibilities

• Design and implement stage-appropriate DMPK strategies with AI-first approach.
• Design screening cascades and mechanistic experiments to support project progression.
• Integrate DMPK, PD and toxicology data to inform dose and safety windows.

Skills

DMPK leadership

Cross-functional leadership

PKPD expertise

Regulatory documentation

Strategic thinking

Communication

Data integration

Education

PhD in Pharmaceutical Science/Pharmacy/Chemistry

Tools

R

Python

KNIME

Job description

Isomorphic Labs is seeking a DMPK Lead to drive the DMPK strategy across drug discovery projects, coordinating with cross-functional teams to deliver high-quality clinical candidates. You will integrate pharmacokinetics, translational research, and regulatory considerations, leveraging AI-enabled models and state-of-the-art data integrations to inform decision making.

The role requires extensive experience in DMPK across multiple modalities, collaboration with preclinical and clinical teams, and