DMPK & Quantitative Pharmacology Lead for AI Drug Design

Isomorphic Labs; Cambridge; Hybrid; GBP 90,000 - 140,000; Full time

Job summary

Isomorphic Labs is seeking a senior DMPK Lead to drive DMPK strategies across drug discovery projects in a hybrid Cambridge setting. You will shape AI-first ADME approaches, integrate multi-omics data, and collaborate with Preclinical and Clinical teams to advance clinical candidates.

The role requires a PhD and 7–10+ years of DMPK experience in biotech or pharma, with strong PK/ADME modelling and regulatory writing capabilities.

Qualifications

• PhD in Pharmaceutical Science, Pharmacy or Chemistry or related field.
• 7–10+ years in a DMPK role within biotech/pharma settings.
• Experience authoring regulatory documents and collaborating with preclinical/clinical teams.

Responsibilities

• Design stage-appropriate DMPK strategies with an AI-first approach.
• Develop screening cascades and mechanistic experiments for project progress.
• Integrate DMPK, PD and toxicology data for decision support.
• Define Quantitative Pharmacology strategy with Pharmacology Leads.
• Advance datasets and design methods to improve human PK prediction.
• Contribute to molecule design with chemistry leads and biotransformation knowledge.
• Author DMPK sections of regulatory submissions and reports.
• Promote inclusion and ongoing professional development.
• Collaborate with AI Platform teams on drug design projects.

Skills

DMPK strategy

Data integration

Biotransformation knowledge

PK modelling

Collaborative drug discovery

Education

PhD in Pharmaceutical Science, Pharmacy or Chemistry

Tools

Python

R

ADME modelling tools

Job description

Isomorphic Labs is seeking a senior DMPK Lead to drive DMPK strategies across drug discovery projects in a hybrid Cambridge setting. You will shape AI-first ADME approaches, integrate multi-omics data, and collaborate with Preclinical and Clinical teams to advance clinical candidates.

The role requires a PhD and 7–10+ years of DMPK experience in biotech or pharma, with strong PK/ADME modelling and regulatory writing capabilities.