Genomics Research Assistant — Bone & Cartilage Regulation

Diversity Dashboard; Manchester; Hybrid; GBP 28,000 - 34,000; Full time

Benefits offered by this job

Hybrid working arrangements

Job summary

The University of Manchester seeks a Research Assistant for the Rice Lab in the Division of Musculoskeletal and Dermatological Sciences. This two-year role contributes to a functional genomics programme examining how genetic variation influences gene regulation and skeletal traits.

Responsibilities include characterising non-coding regulatory elements in bone and cartilage cells, using CRISPR-Cas9 genome editing in human cell models, and culturing primary human cells and human tissues under

Qualifications

• Knowledge of mammalian cell culture, aseptic technique and core molecular biology principles.
• Ability to plan and prioritise multi-stage experimental work and deliver reproducible results.
• Ability to analyse, interpret and clearly present experimental data in written and oral formats.

Responsibilities

• Delivering a defined programme of experimental research under the direction of Dr Sarah Rice, planning and prioritising day-to-day experimental activity and regularly discussing progress and priorities.
• Culturing and maintaining established human cell lines, mesenchymal stromal cells and primary human cells using high-quality aseptic technique.
• Generating and validating targeted regulatory-element deletions and other experimental cell models using CRISPR-Cas9 genome editing and related molecular approaches.
• We welcome candidates who bring diverse perspectives, experiences, and approaches to their work.

Skills

Mammalian cell culture

Aseptic technique

Molecular biology principles

Experimental design

Data presentation (written/oral)

Tools

CRISPR-Cas9

Genome editing

Job description

The University of Manchester seeks a Research Assistant for the Rice Lab in the Division of Musculoskeletal and Dermatological Sciences. This two-year role contributes to a functional genomics programme examining how genetic variation influences gene regulation and skeletal traits.

Responsibilities include characterising non-coding regulatory elements in bone and cartilage cells, using CRISPR-Cas9 genome editing in human cell models, and culturing primary human cells and human tissues under