Consultant Call - Preclinical pharmacology consultant (Peptide Therapeutics)

Constructive Bio; Cambridgeshire and Peterborough; Remote; GBP 80,000 - 100,000; Part time

Job summary

A biotechnology firm is seeking an experienced DMPK consultant to support peptide therapeutic development. Responsibilities include planning in vivo/in vitro studies, advising on DMPK strategy, and analyzing data. The ideal candidate has a proven track record in DMPK for peptides or biologics and is available for short- or medium-term consulting. Strong communication skills are essential.

Qualifications

• Track record in DMPK for peptides or biologics.
• Experience with PK/PD modelling and half-life extension technologies.
• Ability to provide strategic guidance and hands-on analysis.

Responsibilities

• Plan and review in vivo studies.
• Plan and review in vitro assays.
• Advise on overall DMPK strategy for peptides.
• Analyze data and recommend next steps.
• Support vendor/CRO selection and study oversight.

Skills

DMPK expertise for peptides

PK/PD modelling

Strong communication skills

Job description

Overview

Consultant Call - DMPK (Peptide Therapeutics). Constructive Bio is seeking an experienced DMPK or PK/PD (preclinical pharmacology) consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now. We are open to short- or medium-term consulting arrangements.

Responsibilities

• Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
• Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
• Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
• Analyse data, highlight risks, and recommend next steps to guide project teams.
• Benchmark against industry best practices and prepare input suitable for preclinical packages.
• Support vendor/CRO selection and study oversight.

Requirements

• Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
• Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
• Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
• Strong communication skills to work with internal scientists and external partners.

Desirable

• Experience of in vitro and in vivo safety and toxicology studies
• Knowledge and preparation of IND documents would be an advantage