Associate Principal DMPK Scientist - Lead Drug Discovery

Pharmaron; Hoddesdon; Presencial; GBP 85.000 - 110.000; Jornada completa

Descripción de la vacante

Pharmaron Hoddesdon is seeking an experienced Associate Principal Scientist in DMPK to join our Integrated Drug Discovery team. You will provide scientific leadership across DMPK, ADME and PK activities, develop study strategies for small-molecule programmes, and translate complex datasets into actionable recommendations.

Lead cross-disciplinary teams, design studies, interpret in vitro ADME and in vivo PK data, and support client interactions.

Formación

• A BSc, MSc or PhD or equivalent experience in pharmacology, pharmaceutical sciences or related discipline.
• Significant experience supporting DMPK drug discovery or development programmes.
• Strong knowledge of in vitro ADME and in vivo PK principles, assays and how physicochemical properties impact these properties.
• Experience designing studies and interpreting complex PK and ADME datasets.
• Knowledge of IVIVE, human PK prediction and dose prediction methodologies.
• Familiarity with PBPK modelling approaches and relevant software is an advantage.
• Experience working within multidisciplinary drug discovery teams.
• Previous pharmaceutical, biotechnology or CRO experience.

Responsabilidades

• Provide scientific leadership across integrated DMPK, ADME and PK activities.
• Develop fit-for-purpose study and screening strategies for small-molecule discovery programmes.
• Interpret and integrate in vitro ADME, in vivo PK and multidisciplinary project data.
• Conduct IVIVE, human PK and dose predictions, using state of the art techniques.
• Translate complex DMPK data into clear recommendations that support project decisions.
• Troubleshoot scientific and technical issues relating to DMPK and ADME studies.
• Prepare and present high-quality reports, data summaries and scientific recommendations.
• Act as a scientific point of contact for clients and multidisciplinary project teams.
• Coordinate DMPK activities across our global organisation to support timely and effective project delivery.

Educación

BSc/MSc/PhD or equivalent in pharmacology/pharmaceutical sciences

Descripción del empleo

Pharmaron Hoddesdon is seeking an experienced Associate Principal Scientist in DMPK to join our Integrated Drug Discovery team. You will provide scientific leadership across DMPK, ADME and PK activities, develop study strategies for small-molecule programmes, and translate complex datasets into actionable recommendations.

Lead cross-disciplinary teams, design studies, interpret in vitro ADME and in vivo PK data, and support client interactions.