Associate Principal Scientist, DMPK

Pharmaron; Hoddesdon; On-site; GBP 85,000 - 110,000; Full time

Job summary

Pharmaron Hoddesdon is seeking an experienced Associate Principal Scientist in DMPK to join our Integrated Drug Discovery team. You will provide scientific leadership across DMPK, ADME and PK activities, develop study strategies for small-molecule programmes, and translate complex datasets into actionable recommendations.

Lead cross-disciplinary teams, design studies, interpret in vitro ADME and in vivo PK data, and support client interactions.

Qualifications

• A BSc, MSc or PhD or equivalent experience in pharmacology, pharmaceutical sciences or related discipline.
• Significant experience supporting DMPK drug discovery or development programmes.
• Strong knowledge of in vitro ADME and in vivo PK principles, assays and how physicochemical properties impact these properties.
• Experience designing studies and interpreting complex PK and ADME datasets.
• Knowledge of IVIVE, human PK prediction and dose prediction methodologies.
• Familiarity with PBPK modelling approaches and relevant software is an advantage.
• Experience working within multidisciplinary drug discovery teams.
• Previous pharmaceutical, biotechnology or CRO experience.

Responsibilities

• Provide scientific leadership across integrated DMPK, ADME and PK activities.
• Develop fit-for-purpose study and screening strategies for small-molecule discovery programmes.
• Interpret and integrate in vitro ADME, in vivo PK and multidisciplinary project data.
• Conduct IVIVE, human PK and dose predictions, using state of the art techniques.
• Translate complex DMPK data into clear recommendations that support project decisions.
• Troubleshoot scientific and technical issues relating to DMPK and ADME studies.
• Prepare and present high-quality reports, data summaries and scientific recommendations.
• Act as a scientific point of contact for clients and multidisciplinary project teams.
• Coordinate DMPK activities across our global organisation to support timely and effective project delivery.

Education

BSc/MSc/PhD or equivalent in pharmacology/pharmaceutical sciences

Job description

Associate Principal Scientist, DMPK

Location: Hoddesdon, Hertfordshire, UK

About the Role

Pharmaron is seeking an experienced Associate Principal Scientist, DMPK to join our Integrated Drug Discovery team in Hoddesdon.The Integrated Drug Discovery (IDD) Services group at Pharmaron is responsible for leading and delivering drug discovery projects for our client partners. The team comprises scientific expertise and strategic leadership across medicinal chemistry, CADD, biology, DMPK and translational science. Combined with Pharmaron’s global research capabilities we design and deliver integrated programmes from target identification and hit finding through to IND filing. Working closely with our partners we define strategy, coordinate execution across teams and with an AI enabled accelerated Design–Make–Test–Analyse cycles support the progression of projects and innovative medicines towards the clinic. This is an exciting opportunity for an experienced DMPK scientist to provide scientific leadership across a diverse portfolio of discovery programmes. You will apply your expertise in DMPK, ADME, pharmacokinetics and translational science to guide project strategy, interpret complex datasets and support informed decision-making.

About Pharmaron

Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2004, Pharmaron has established a broad range of drug research and development capabilities spanning synthetic, medicinal and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry, metabolism, chemical and pharmaceutical development, and clinical development. Our Drug Discovery department in Hoddesdon provides scientific leadership to partners across the life sciences industry. Working in collaboration with Pharmaron’s global capabilities and resources, the multidisciplinary team delivers high-quality small-molecule preclinical candidates across a range of therapeutic areas and routes of administration. Our experienced scientists provide scientific leadership, strategy, molecule design and project oversight, helping our partners progress programmes towards candidate nomination and the clinic.

The Opportunity

You will:

• Provide scientific leadership across integrated DMPK, ADME and PK activities.
• Develop fit-for-purpose study and screening strategies for small-molecule discovery programmes.
• Interpret and integrate in vitro ADME, in vivo PK and multidisciplinary project data.
• Conduct IVIVE, human PK and dose predictions, using state of the art techniques.
• Translate complex DMPK data into clear recommendations that support project decisions.
• Troubleshoot scientific and technical issues relating to DMPK and ADME studies.
• Prepare and present high-quality reports, data summaries and scientific recommendations.
• Act as a scientific point of contact for clients and multidisciplinary project teams.
• Coordinate DMPK activities across our global organisation to support timely and effective project delivery.

About You

Qualifications and Experience

• A BSc, MSc, PhD or equivalent experience in pharmacology, pharmaceutical sciences or a related discipline.
• Significant experience supporting DMPK drug discovery or development programmes.
• Strong knowledge of in vitro ADME and in vivo PK principles, assays and how physicochemical properties impact these properties.
• Experience designing studies and interpreting complex PK and ADME datasets.
• Knowledge of IVIVE, human PK prediction and dose prediction methodologies.
• Familiarity with PBPK modelling approaches and relevant software is an advantage.
• Experience applying DMPK science to small-molecule discovery programmes With experience with other modalities an advantage.
• Experience working within multidisciplinary drug discovery teams.
• Previous pharmaceutical, biotechnology or CRO experience.

Professional Attributes

• Confident in providing scientific direction and technical recommendations.
• Able to communicate complex findings clearly to scientific teams and clients.
• Collaborative, client-focused and comfortable working across global teams.
• Organised and able to manage priorities across multiple projects.
• Proactive in identifying scientific challenges and developing practical solutions.
• Committed to scientific quality, continuous improvement and knowledge sharing.

Why Join Pharmaron?

• Join a global, industry-leading drug discovery organisation.
• Contribute to drug discovery programmes from hit finding through to candidate nomination and IND.
• Collaborate with specialists across medicinal chemistry, biology, pharmacology, DMPK and translational science.
• Access Pharmaron’s global scientific capabilities and research platforms.
• Work in a state-of-the‑art scientific environment at our Hoddesdon site.
• Develop your career within a collaborative and growing organisation.