Study Engineer (M/F)

Institut Curie - Research Center; France; Sur place; EUR 29 000 - 30 000; Plein temps

Avantages offerts par ce poste

Collective catering

Transport reimbursement up to 70%

Supplementary health insurance

Résumé du poste

The Institut Curie - Research Center is seeking a motivated Study Engineer (IE) in Biology to contribute to cancer research using hiPSCs, hiPSC-derived cells, and neuroblastoma lines. You will maintain cell cultures, perform gene modulation with CRISPR, and assist with molecular analyses to understand tumor initiation and progression.

The role requires a Master’s degree in molecular biology, 1–2 years of relevant experience, and strong English skills.

Qualifications

• Master’s degree in molecular and cellular biology or related field.
• 1–2 years of hands-on experience in mammalian cell culture and hiPSC/hESCs (mandatory).
• Solid background in cellular and molecular biology techniques (PCR, RT-qPCR, western blot, cloning, plasmids).

Responsabilités

• Maintain and differentiate hiPSCs and culture multiple cell lines.
• Perform transfection experiments and molecular assays (including CRISPR) to modulate and analyze gene expression.
• Extract DNA, RNA and protein, followed by downstream analyses (PCR, RT-qPCR, western blot).
• Apply molecular biology techniques such as cloning and plasmid manipulation.
• Collaborate closely with researchers to analyze data and advance the project.

Connaissances

hiPSC culture

Mammalian cell culture

PCR/RT-qPCR

Plasmid cloning

CRISPR

Formation

Master's degree in molecular and cellular biology

Outils

CRISPR

DNA/RNA extraction

Description du poste

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile First Stage Researcher (R1) Positions Master Positions Application Deadline 30 Sep 2026 - 00:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 8 Jul 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The Curie Institute Research Center

The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Description of position

Laboratory

Institut Curie, CNRS UMR 144 – team Daniele Fachinetti: Molecular Mechanisms of Chromosome Dynamics

Missions

Our team Molecular Mechanisms of Chromosome Dynamics, led by Daniele Fachinetti, investigates the fundamental principles that ensure the faithful transmission of genetic material in mammalian cells. We combine cell biology, genetics, epigenetics, biochemistry, and imaging to understand how centromeres are established, maintained, and function throughout the cell cycle. We also study how their deregulation can lead to genome instability – a key driver of many pathologies, including cancer.

Our team is seeking a motivated Study Engineer (IE) in Biology to contribute to a project investigating the role of aneuploidy, centromeres, and germline deletions in the transition from normal to tumoral states in neuroblastoma. The project focuses on human induced pluripotent stem cells (hiPSCs), hiPSC-derived sympathoblasts, and neuroblastoma cell lines to better understand mechanisms of tumor initiation and progression.

The successful candidate will be responsible for:

• Maintenance and differentiation of hiPSCs and culture of several cell lines.
• Performing transfection experiments and molecular assays (including CRISPR technology) to modulate and analyze gene expression.
• Conducting DNA, RNA, and protein extraction followed by downstream analyses (PCR, RT-qPCR, western blot).
• Applying molecular biology techniques such as cloning and plasmid manipulation.
• Collaborating closely with researchers to analyze experimental data and contribute to the advancement of the project

Profile

Education and competences

• Education: Master’s degree (MSc) in molecular and cellular biology, biotechnology, or a related field.
• Experience: At least 1-2 years of hands‑on experience in mammalian cell culture and hiPSC/hESCs (mandatory).
• Solid background in cellular and molecular biology techniques (PCR, RT-qPCR, western blot, cloning, plasmids).

Qualifications

• Good organizational skills, ability to work both independently and in a team.
• Rigor, motivation, and enthusiasm for research.
• Fluency in English

All our opportunities are open to people with disabilities

Contract information

Type of contract : CDD

Working time : full time

Remuneration:from 29240.67 to 30396.75€/year according to the current grids

Benefits:Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.