Postdoctoral Researcher (M/F) in Cellular Biophysics

CNRS - National Center for Scientific Research; France; Sur place; EUR 32 000 - 42 000; Plein temps

Résumé du poste

The postdoctoral researcher will join the DEVIN project at IPBS (Toulouse) within the Cellular Biophysics team to explore DNA electropermeabilization and membrane interactions using experimental and numerical modeling approaches.

The role combines GUV preparation, electroporation experiments, fluorescence microscopy, and data-driven comparisons with COMSOL-based models, culminating in publications and dissemination of results.

Qualifications

• PhD in biophysics, applied physics, biomedical engineering, or related discipline.
• Postdoctoral experience in cell biology and fluorescence microscopy.
• Experience with electroporation and membrane biophysics.
• Programming in Python; image analysis with ImageJ/Fiji.

Responsabilités

• Prepare and characterize giant unilamellar vesicles (GUVs).
• Perform electroporation experiments on lipid membranes and cultured cells.
• Investigate membrane permeabilization, morphological changes and lipid peroxidation.
• Culture adherent cells and conduct plasmid DNA transfer experiments.
• Use optical/fluorescence microscopy and quantitative image analysis.
• Process experimental data and compare with numerical models.
• Present research findings and write scientific publications.

Connaissances

Cell biology

Fluorescence microscopy

Python programming

ImageJ/Fiji

Electroporation

Biophysics

GUV preparation

Formation

PhD in biophysics, applied physics, biomedical engineering, or related discipline

Outils

COMSOL Multiphysics

ImageJ/Fiji

Description du poste

Organisation/Company CNRS Department Institut de Pharmacologie et Biologie Structurale Research Field Mathematics History » History of science Researcher Profile Recognised Researcher (R2) Application Deadline 17 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Dec 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The postdoctoral researcher will participate in the DEVIN project (Numerical Modeling of DNA Electroporation Vaccination), which aims to investigate the physical mechanisms underlying the electropermeabilization of biological membranes and DNA transfer using pulsed electric fields. They will conduct experimental work on membrane and cellular models, in connection with the numerical modeling approaches developed within the project, and contribute to the dissemination and promotion of the scientific results.

• Preparation and characterization of giant unilamellar vesicles (GUVs).
• Conducting electroporation experiments using pulsed electric fields on lipid membranes and cultured cells.
• Investigating membrane permeabilization, morphological changes, and lipid peroxidation.
• Culturing adherent cells and conducting plasmid DNA transfer experiments.
• Optical and fluorescence microscopy, image acquisition, and quantitative image analysis.
• Processing and analyzing experimental data and comparing the results with numerical models.
• Presenting research findings and writing scientific publications.

The position is based at the IPBS (Institute of Pharmacology and Structural Biology) in Toulouse, within the Cellular Biophysics team, which specializes in the interactions between electric fields and biological systems.

The DEVIN project brings together the IPBS, the Inria Centre at the University of Rennes, and the Ampère laboratory in Lyon, fostering collaboration between experimental biophysics and numerical modeling.

• PhD in biophysics, applied physics, biomedical engineering, or a related discipline.
• Expertise and postdoctoral experience in cell biology and fluorescence microscopy.
• Expertise in the interactions between electric fields and biological systems, with hands‑on experience in electroporation.
• Knowledge of membrane biophysics and molecular transport.
• Experience in finite element numerical modeling (COMSOL Multiphysics or equivalent).
• Proficiency in image analysis (ImageJ/Fiji) and scientific programming in Python.
• Experience in lipid vesicle preparation, nonlinear microscopy, or extracellular matrix characterization would be an advantage.

Independence, scientific rigor, the ability to work as part of a team, and proficiency in scientific English are essential.