Post-Doctoral Researcher/Research Scientist Position in Vaccine Immunology

Institut Pasteur; Paris; On-site; EUR 40,000 - 55,000; Full time

Job summary

Institut Pasteur in Paris, France, invites applications for a Post-Doctoral Researcher/Research Scientist position focused on vaccine immunology. The role centers on mRNA-LNP vaccines and the immune mechanisms driving T cell responses, with emphasis on dendritic cells and memory T cell dynamics.

The candidate will design experiments, conduct animal vaccination schedules in mice, analyze data, supervise M1/M2 students, collaborate with bioinformatic engineers, and prepare publication-ready

Qualifications

• A solid scientific background in immunology (dendritic cells, T cell biology, airway immunology, influenza immunology…).
• A strong interest in vaccine immunology.
• Project leadership, drive and dynamism.
• Competences in bioinformatics are a strong asset for this position.
• Carrer development in academic research will be strongly supported by the laboratory.

Responsibilities

• Design experiments and formalize experimental protocols.
• Organize and conduct animal experimentation and vaccination schedules in mice.
• Analyze experimental data and keep organized data archives in compliance with local policies.
• Participate actively to M1/M2 student supervision.
• Interact and collaborate productively with other researchers within and outside of the team, including bioinformatic engineers.
• Present data in lab meetings, collaborative meetings and communicate research outputs in scientific meetings.
• Produce publication-ready figures for grant applications and manuscripts for publication.

Skills

Immunology

T cell biology

Dendritic cells

Vaccine immunology

Education

PhD degree

Tools

Bioinformatics

Job description

Post-Doctoral Researcher/Research Scientist Position in Vaccine Immunology

Institut Pasteur
Paris, France

Background:

We are seeking a highly motivated researcher to join our laboratory to work on mRNA-Lipid nanoparticle (LNP) vaccines. These vaccines offer a unique and versatile technological platform that enables rapid vaccination against emerging pathogens. Despite the major successes seen in SARS-CoV-2 vaccination, current mRNA vaccines elicit CD8+ T cell responses that are less potent and long-lasting than those produced by other non-replicative viruses. Because T cell immunity underlies heterotypic protection against viral strains that escape the neutralizing antibodies generated by vaccines, understanding these responses is critical. Currently, the exact mechanisms underlying the activation of T cell responses against mRNA vaccines remain poorly understood.

Key Responsibilities and Objectives:

• Better characterizing the complex interactions between mRNA vaccines and various DC subsets, including XCR1+IRF8+ DCs, IRF4+ DCs (DC2As, DC2Bs, DC3s), and plasmacytoid DCs (pDCs and pDCs-like);
• Defining the specific role of these DC subsets in controlling the activation and trafficking properties of memory T cell pools. In this context, you will be investigating how DCs impact on multiple types of memory T cells to recall responses, specifically focusing on circulating memory cells (TCIRCM), memory cells with a tropism for lymphoid organs (TCM), and Tissue-resident memory cells (TRM).

Candidate profile:

• A former working experience and training/habilitation in animal experimentation (mandatory);
• A PhD level, preferably without former postdoctoral experience or research compatible training such as engineer schools;
• A solid scientific background in immunology (dendritic cells, T cell biology, airway immunology, influenza immunology…);
• A strong interest in vaccine immunology;
• Project leadership, drive and dynamism.
• Competences in bioinformatics are a strong asset for this position.
• Carrer development in academic research will be strongly supported by the laboratory.

Missions:

• Design experiments and formalize experimental protocols;
• Organize and conduct animal experimentation and vaccination schedules in mice;
• Analyze experimental data and keep organized data archives in compliance with local policies;
• Participate actively to M1/M2 student supervision;
• Interact and collaborate productively with other researchers within and outside of the team, including bioinformatic engineers;
• Present data in lab meetings, collaborative meetings and communicate research outputs in scientific meetings;
• Produce publication-ready figures for grant applications and manuscripts for publication.

Deadline 31 December