Postdoctoral Researcher (m/f/d) - Antibody Characterization & Wet-Lab Validation

BioMed X; Paris; Sur place; EUR 45 000 - 65 000; Plein temps

Avantages offerts par ce poste

Mentoring and training

International, diverse team

Résumé du poste

BioMed X, a leader in AI-driven biomedical research, seeks a postdoctoral researcher to lead the wet-lab characterization arm of its AI-guided bispecific antibody discovery program. You will join Team ADB within BioMed X’s XSeed Labs, working at the bench and collaborating with computational scientists to advance rational antibody design.

You will design and execute experiments, manage data integrity, and liaise with CROs as needed, in a fast-paced, interdisciplinary environment at Servier’s R&D

Qualifications

• PhD in Structural Biology, Life Sciences, Biochemistry, or related field.
• Hands-on protein expression/purification and thermostability assays.
• Characterisation of protein/antibody–antigen complexes (BLI/SPR, BRET/FRET, X-ray/cryo-EM).
• Proven track record of independent project management.
• Publication record and strong scientific writing.
• Excellent oral and written communication.

Responsabilités

• Set up and run the lab's core characterisation pipeline (protein expression, purification, thermostability, binding assays).
• Design experiments to test hypotheses and explain outcomes.
• Own wet-lab data integrity and integrate datasets with computational results.
• Manage CRO relationships for external capacity.
• Collaborate with computation scientists to close design-test-learn loop.

Formation

PhD in Structural Biology, Life Sciences, Biochemistry, or closely related field

Outils

Protein expression & purification

Thermostability assays

Biophysical characterization (BLI/SPR, BRET/FRET, X-ray/cryo-EM)

Project management

Publications

Communication skills

Multiple expression systems

FACS/MACS-based assays

Computational protein design

Description du poste

BioMed X is a leading innovation engine where disruptive ideas in biomedical research and development come to life. With our global network of research institutes and venture-creating incubators, embedded within major innovation hubs, we bridge the gap between academic research and the needs of the pharmaceutical industry.

We are pioneers in applying the principles of design thinking and crowdsourcing to drug discovery and development. With our unique model, we partner with pharma, venture capital, and patient-focused foundations to identify key challenges across all therapeutic areas, recruit top talent, and co-create tailored solutions.

In our stimulating ecosystem, talented researchers from all around the globe grow into industry-ready scientific leaders. They perform exploratory research, deliver industry-grade results, and pave the way for next-generation therapies. At BioMed X, we value curiosity, diversity, and purpose. Together, we serve as a vital catalyst for innovation in global health – for the benefit of all patients.

Through its XSeed Labs model, BioMed X embeds independent research teams within the R&D environments of industry partners, enabling close scientific interaction while maintaining academic independence. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds - academia and industry - and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

About Team ADB (AI-Empowered Platform for Sterically Guided Design of Bispecific Antibodies)

Team ADB is a newly established research team within BioMed X’s XSeed Labs program. The team will develop AI-enabled platform for the rational design of bispecific antibodies, addressing key limitations such as steric hindrance, epitope accessibility, spatial dynamics, and physiological constraints that currently limit the systematic development of immune cell engagers (ICEs) and dual-targeting antibody–drug conjugates (ADCs).

In close collaboration with Servier, the team operates at the interface of academia and industry, translating advances in antibody engineering, structural biology, and machine learning into geometry-aware design strategies with high translational relevance. The team will be based on Servier’s R&D campus in Paris-Saclay, near Paris, France, enabling close, day-to-day interaction with industry scientists.

The Position

We're looking for a postdoctoral researcher to build and lead the wet-lab characterization arm of our AI-guided bispecific antibody discovery program.

You’ll be part of a team combining computational structural biology, machine learning, and antibody engineering to design next generation bispecifics.

Key Responsibilities

• Set up and run the lab’s core characterisation pipeline with our biological engineer: protein expression and purification, thermostability assays, and standard PPI binding assays.
• Design experiments and assays to test hypotheses generated by the team and help pinpoint why designs succeed or fail.
• Own wet-lab data integrity, traceability, and the consolidation of experimental and computational datasets.
• Manage CRO relationships where external capacity is needed (e.g., protein production, specialised assays).
• Work closely with computational scientists to close the design-test-learn loop.

Required skills

The ideal candidate will have:

• A PhD in Structural Biology, Life Sciences, Biochemistry, or a closely related field.
• Hands‑on expertise in protein expression/purification, thermostability assay, characterisation of protein and antibody‑antigen complex (BLI/SPR, BRET/FRET, Xray/cryoEM).
• Track record of independent project management, able to own a workstream end to end.
• Publication record demonstrating research rigor and output.
• Strong oral and written communication skills.

Additional skills, good to have

• Experience across multiple expression systems (yeast, bacterial, mammalian).
• Familiarity with complementary analytical/QC techniques.
• FACS or MACS‑based binding or functional assays.
• Familiarity with computational protein design.

What we offer

• A fully funded research position immediately available within a high-profile BioMed X XSeed Labs project in collaboration with Servier.
• Open-ended contract (CDI) under French labour law.
• A strong mentoring and training environment, with close interaction with senior scientists in AI/ML, structural biology, and antibody research.
• Direct exposure to AI‑enabled antibody discovery workflows at the academia–industry interface.
• Opportunities to contribute to scientific publications and conference presentations, aligned with project objectives and confidentiality requirements.
• An international, diverse, and collaborative work environment based on Servier’s R&D campus in Paris‑Saclay.
• A role that provides excellent preparation for doctoral studies or computational careers in biomedical research.

At BioMed X we embrace diversity as we consider it the source of innovation. We are committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, ideology, sex, sexual orientation, age, gender identity or gender expression, national origin, or disability.

To read about us, please visit: https://bmedx.com