Postdoctoral Researcher | Institute Pasteur

Biopractify

Paris

Hybrid

EUR 42,000 - 56,000

Full time

14 days+

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Benefits offered by this job

International collaboration

ANR-funded project

Access to institute facilities

Job summary

Institut Pasteur in Paris invites applications for an ANR-funded postdoctoral fellowship in the Biology and Genetics of the Bacterial Cell Wall Unit. The project focuses on how H. pylori releases peptidoglycan fragments and shapes host immune responses.

Research spans microbiology, mass spectrometry, organoid models, gut-on-chip, and in vivo systems with collaboration from TUM and Monash. The successful candidate will work in an interdisciplinary environment, contribute to publications, and

Qualifications

Strong background in microbiology.
Experience or strong expertise in organoid research.
Interest in microbiome, bacterial cell-wall biology, and host–microbe interactions.
Experience with LC-MS/MS or mass spectrometry is an advantage.
Experience with animal models is an advantage.
Strong interest in studying how bacterial molecules shape host immune responses.
Ability to work effectively in an interdisciplinary and collaborative research environment.

Responsibilities

Study how Helicobacter pylori interacts with the host and contributes to immune-system regulation through the release of peptidoglycan fragments.
Investigate mechanisms involved in release and processing of bacterial peptidoglycan fragments and their effects on host responses.
Apply mass spectrometry and LC-MS/MS approaches to characterize bacterial cell-wall-derived molecules.
Use organoid systems to investigate host–microbe interactions and understand how bacterial molecules influence host biology.
Work with gut-on-chip platforms and in vitro models to study bacterial–host interactions.
Use animal models to investigate the biological effects and mechanisms of bacterial peptidoglycan fragments in vivo.
Apply confocal microscopy and cellular imaging approaches to study bacterial interactions and immune-related processes.

Skills

Microbiology

Organoid research

Microbiome

Mass spectrometry

LC-MS/MS

Host–microbe interactions

Tools

LC-MS/MS

Job description

Institution: Institute Pasteur – Biology and Genetics of the Bacterial Cell Wall Unit

The Institut Pasteur is inviting applications for an ANR-funded postdoctoral fellowship in the Biology and Genetics of the Bacterial Cell Wall Unit, headed by Ivo G. Boneca.

The project investigates how gut bacteria, particularly Helicobacter pylori, release peptidoglycan fragments and how these bacterial molecules influence and shape the host immune system.

The successful candidate will work in an interdisciplinary environment and collaborate with research teams from the Technical University of Munich and Monash University.

What You’ll Work On

Study how H. pylori interacts with the host and contributes to immune-system regulation through the release of peptidoglycan fragments.

Bacterial Cell Wall Biology

Investigate the mechanisms involved in the release and processing of bacterial peptidoglycan fragments and their effects on host responses.

Mass Spectrometry

Apply mass spectrometry and LC-MS/MS approaches to characterize bacterial cell-wall-derived molecules and peptidoglycan fragments.

Use organoid systems to investigate host–microbe interactions and understand how bacterial molecules influence host biology.

Work with advanced experimental systems, including gut-on-chip platforms and in vitro models, to study bacterial–host interactions.

Use animal models to investigate the biological effects and mechanisms of bacterial peptidoglycan fragments in vivo.

Confocal Microscopy

Apply confocal microscopy and cellular imaging approaches to study bacterial interactions and immune-related processes.

The ideal candidate should have:

A strong background in microbiology.
Experience or strong expertise in organoid research.
Interest in microbiome, bacterial cell-wall biology, and host–microbe interactions.
Experience with LC-MS/MS or mass spectrometry is an advantage.
Experience with animal models is an advantage.
Strong interest in studying how bacterial molecules shape host immune responses.
Ability to work effectively in an interdisciplinary and collaborative research environment.

What You’ll Gain

Opportunity to work at Institut Pasteur, a leading international biomedical research institution.
Work on an ANR-funded postdoctoral research project.
Experience investigating microbiome–host interactions and bacterial cell-wall biology.
Training and research experience with mass spectrometry, confocal microscopy, organoids, gut-on-chip systems, and in vivo models.
International collaboration with researchers at the Technical University of Munich and Monash University.
Opportunity to contribute to research addressing fundamental questions in microbiology and immunology.
Work within the Biology and Genetics of the Bacterial Cell Wall Unit, led by Ivo G. Boneca.

The project builds on previous research investigating the dissemination of peptidoglycan fragments across the body from the gut.

The successful postdoctoral researcher will study how Helicobacter pylori releases peptidoglycan fragments and how these molecules interact with and influence the host immune system.

The project will combine microbiology, mass spectrometry, confocal microscopy, organoid models, gut-on-chip systems, and animal models to investigate these mechanisms.

The research is conducted in collaboration with teams from the Technical University of Munich (TUM) and Monash University.

The successful candidate will be expected to:

Investigate peptidoglycan fragment release by H. pylori.
Study the mechanisms through which bacterial molecules shape host immune responses.
Perform experiments using in vitro, organoid, gut-on-chip, and in vivo models.
Apply mass spectrometry and microscopy-based approaches.
Analyze bacterial cell-wall-derived molecules and their biological effects.
Collaborate with international research teams.
Disseminate research findings through scientific publications and conferences.