Post-doc position in my group at Institut Pasteur Paris in the field of cell/tissue biology and host-pathogen interactions !

Société de Biologie Cellulaire de France (SBCF); Paris; Sur place; EUR 42 000 - 52 000; Plein temps

Résumé du poste

The ColOx project at Institut Pasteur in Paris invites applications for two postdoctoral researchers to study how O2 levels regulate the human colonic barrier using organ-on-chip models and infection challenges.

The 36‑month position joins the Tissue homeostasis group in Paris, under Nathalie Sauvonnet. Applications close 19/09/2026; please email [e-mail] with your CV and a brief statement of research interests.

Description du poste

We are delighted to announce that our Colox project has received funding from the ANR!

We are recruiting two postdoctoral researchers at the Institut Pasteur in Paris.

One of them will be recruited for a period of 36 months to join my group https://research.pasteur.fr/en/team/group-nathalie-sauvonnet/.

Role

The ColOx project aims to define the role of O₂ levels in the human colonic barrier under physiological and infectious conditions by challenging the system with CD infection and neutrophils.

Project objectives are to determine:

• Mapping of O2 tensions in human colon-on-chip upon several O₂ tension configurations
• Impact of O2 variation on the epithelial and mucus layers under physiological condition
• Impact of O2 gradient on colonic barrier under infection condition using CD as a challenger
• Impact of hypoxia on the CD and neutrophils interplay

By integrating patient-derived colonic organoids, endothelial and immune cells into organ-on-chip devices exposed to controlled O₂ environments, ColOx enables causal studies of epithelial, microbial, and immune interactions. Using an interdisciplinary approach—including live O₂ mapping, transcriptomic analyses, mucus characterization, CD infection assays, and neutrophil functional studies—ColOx will generate novel insights into how O₂ regulates barrier function and host–microbe dynamics in health and disease.

Contact information

Date limite 19/09/2026

nathalie sauvonnet

[e-mail]

0145688433

Site web

Tissue homeostasis group at BMcf IP paris

institut Pasteur

paris

FR

Post-doc position in my group at Institut Pasteur Paris in the field of cell/tissue biology and host-pathogen interactions !