Wavefront control and advanced detection for deep-tissue microscopy (M/F)

CNRS - National Center for Scientific Research; France; On-site; EUR 40,000 - 50,000; Full time

Job summary

The Laboratory for Optics and Biosciences (LOB) at École Polytechnique, Palaiseau, France, part of CNRS, seeks a postdoctoral scientist with advanced experience in wavefront control and multiphoton microscopy.

The successful candidate will develop adaptive optics approaches for imaging live and thick samples, focusing on in-depth and longitudinal imaging in zebrafish and mice, with access to state-of-the-art sources and computing facilities.

Qualifications

• PhD in optical imaging required.
• Experience with wavefront shaping, microscope design, 2P/3P microscopy, FLIM, and image processing.
• Strong interdisciplinary collaboration with biologists is a plus.

Responsibilities

• Develop imaging approaches for live and thick samples.
• Advance adaptive optics strategies to improve deep, longitudinal, and multi-contrast imaging.
• Collaborate with biologists and engineers at LOB and EP.

Skills

Wavefront control

Multiphoton microscopy

Biomicroscopy research

Education

PhD in optical imaging

Job description

Organisation/Company CNRS Department Laboratoire d'optique et biosciences Research Field Physics Researcher Profile Recognised Researcher (R2) Application Deadline 2 Dec 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Feb 2027 Is the job funded through the EU Research Framework Programme? Horizon Europe - ERC Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The “advanced microscopies and tissue physiology” group at the Laboratory for Optics and Biosciences (LOB), Ecole Polytechnique, Palaiseau, France, is seeking one postdoctoral scientist with advanced experience in wavefront control, multiphoton microscopy, and interest in interdisciplinary biomicroscopy research.

The successful candidate will develop approaches for imaging of live and thick samples. In particular, based on an existing 2- and 3-photon microscopy platform (Ferrer Ortas, Light Sci App 2023 https://doi.org/10.1038/s41377-022-01064-4 ; Guesmi, Light Sci App 2018 https://doi.org/10.1038/s41377-018-0012-2 ), the project will explore adaptive optics strategies to improve in-depth, longitudinal, and multicontrast imaging in zebrafish and mice.

Ecole Polytechnique is located in the Paris-Saclay area, 25 km South from Paris. The LOB has extensive expertise in multiphoton imaging, and develops advanced microscopy and bioimage informatics approaches for studying developing tissues. The selected person will have access to optics rooms with functional prototypes, state-of-the art femtosecond sources, local workshops, biology facilities, and storage/computing servers. He/she/they will have daily contacts with 3-4 persons, weekly meetings with the LOB microscopy group, and interactions with biologist collaborators.

A PhD in optical imaging is requested. Previous experience in the following topics is expected: wavefront shaping, microscope design and implementation, 2P/3P microscopy, FLIM imaging, numerical simulations, image processing.