Postdoctoral Fellow in Quantitative and Qualitative workflows for Antisense Oligonucleotides

Servier; Gif-sur-Yvette; Sur place; EUR 48 000 - 60 000; Plein temps

Avantages offerts par ce poste

13th-month salary

Profit-sharing / employee participate

Transportation allowance

27 days of paid leave + 23 RTT days

Flexible remote work options depending

On-site company restaurant

Employee committees and activities

Résumé du poste

Servier invites applications for a Postdoctoral Fellow specializing in quantitative and qualitative workflows for antisense oligonucleotides (ASOs). You will develop high-sensitivity methods using Waters microLC with HRMS, and evaluate extraction strategies across plasma, tissues, and CSF.

You will publish at least one peer-reviewed paper and present at international conferences. The role is based at the Paris‑Saclay R&D Institute, with opportunities to contribute to therapeutic progress for

Qualifications

• PhD in bioanalytical science or related analytical chemistry field.
• Proven track record in biological sample preparation and MS workflows.
• Experience with LC and high-resolution MS instrumentation.

Responsabilités

• Design and optimize robust quantitative and qualitative methods for ASOs using microLC and MRT HRMS.
• Systematically evaluate extraction techniques: LLE, SPE, hybridization, spin columns.
• Handle complex biological matrices like plasma, tissues, CSF.
• Analyze data with Waters Connect software and interpret results.
• Prepare and submit at least one peer-reviewed paper and present findings at conferences.
• Document procedures and ensure quality and data integrity.

Connaissances

Mass spectrometry workflows

LC-MS

Analytical chemistry

Scientific communication

Formation

PhD in Bioanalytical Science

Outils

Waters microLC

MRD High-Resolution Mass Spectrometry

Waters Connect software

Liquid-Liquid Extraction (LLE)

Solid Phase Extraction (SPE)

Hybridization-based extraction

Spin columns

Description du poste

Postdoctoral Fellow in Quantitative and Qualitative workflows for Antisense Oligonucleotides

We are a global and independent mid-sized pharmaceutical group governed by a Foundation. Our unique model makes us proud and, more importantly, enables us to fully serve our mission: "committed to therapeutic progress for the benefit of patients."

As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard-to-treat cancers and dedicating more than 70% of our R&D budget to this goal.

Who are we? 20,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

At the heart of one of the world's top eight innovation clusters, the Servier R&D Institute at Paris-Saclay is where visionary science meets a powerful global ecosystem. By uniting our Group's innovation potential with this prestigious center of excellence, we are not only accelerating the future of therapeutic discovery but also championing the global influence of French research.

Are you a fast-learning scientist passionate about pushing the boundaries of bioanalysis for antisense oligonucleotides (ASOs)? We are seeking a Postdoctoral Scientist to join our team. In this role, you will drive the development of high-sensitivity quantitative and qualitative methods for ASOs by leveraging microflow LC coupled with High-Resolution Mass Spectrometry (HRMS), systematically evaluate innovative sample preparation workflows, and contribute to the scientific community through peer-reviewed publications.

Responsibilities

• Method Development: Design and optimize robust quantitative and qualitative bioanalytical methods for ASOs using Waters microLC and MRT High-Resolution Mass Spectrometry.
• Sample Preparation Evaluation: Systematically evaluate and compare various extraction techniques, including Liquid-Liquid Extraction (LLE), Solid Phase Extraction (SPE), hybridization-based extraction, and spin columns.
• Matrix Management: Execute complex sample preparation and analysis across diverse biological matrices, specifically plasma, various tissues, and Cerebrospinal Fluid (CSF).
• Data Analysis & Software: Perform advanced data processing and interpretation using the Waters Connect software suite.
• Scientific Communication: Author and submit at least one high-quality scientific paper for a peer-reviewed journal and present research findings at international scientific conferences (e.g., ASMS, EBF).
• Operational Excellence: Ensure meticulous documentation of experimental procedures and results in alignment with Servier’s internal quality and data integrity standards.

Profile

• PhD in Bioanalytical Science, Biotransformation, Metabolomics, or a related analytical chemistry field.
• Proven track record in biological sample preparation and mass spectrometry workflows.
• Advanced proficiency in Liquid Chromatography (LC) and Mass Spectrometry (MS).
• Hands-on experience with Waters microLC and High-Resolution Mass Spectrometry (MRT).
• Expertise in the Waters Connect software suite.
• Technical mastery of extraction techniques: LLE, SPE, hybridization, and spin columns.
• Experience handling complex matrices (plasma, tissue, CSF).
• Strong communication; excellent organization; scientific rigor; analytical thinking; cooperation mindset; high degree of autonomy.

Our standard recruitment journey includes the following steps:

• Prequalification Interview
• Interview with the Manager
• Interview with Talent Acquisition Team / Human Resources
• Reference Check Process

At one stage of the process, we would be delighted to welcome you to our site to meet in person and share the environment where we work every day to transform patients' lives!

Please note that this recruitment process may be adapted based on the specific requirements of the position.

• 13th-month salary, contribution to results bonus, profit-sharing / employee participation, and transportation allowance
• 27 days of paid leave, plus 23 RTT days (reduced working hours)
• Flexible remote work options depending on the role
• On-site company restaurant, and a wide range of employee committee (CSE) activities and associations

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!